Mechanism of RNA modification N6-methyladenosine in human cancer.

Molecular Cancer
Zijian ZhouHaiwei Yang

Abstract

Since the breakthrough discoveries of DNA and histone modifications, the field of RNA modifications has gained increasing interest in the scientific community. The discovery of N6-methyladenosine (m6A), a predominantly internal epigenetic modification in eukaryotes mRNA, heralded the creation of the field of epi-transcriptomics. This post-transcriptional RNA modification is dynamic and reversible, and is regulated by methylases, demethylases and proteins that preferentially recognize m6A modifications. Altered m6A levels affect RNA processing, degradation and translation, thereby disrupting gene expression and key cellular processes, ultimately resulting in tumor initiation and progression. Furthermore, inhibitors and regulators of m6A-related factors have been explored as therapeutic approaches for treating cancer. In the present review, the mechanisms of m6A RNA modification, the clinicopathological relevance of m6A alterations, the type and frequency of alterations and the multiple functions it regulates in different types of cancer are discussed.

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Citations

Sep 17, 2020·Cancers·Taewan Kim
Mar 8, 2021·Journal of Experimental & Clinical Cancer Research : CR·Yingtong WuJian Zhang
Sep 14, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yujia ZhouXiao Zhu
Apr 29, 2021·RNA Biology·Dianshuang ZhouYan Zhang
May 7, 2021·Journal of Orthopaedic Surgery and Research·Hua LiuZhigang Cai
May 13, 2021·Experimental Eye Research·Nidhi KumariSenthil Kumar Ganesan
Jun 3, 2021·Journal of Cellular and Molecular Medicine·Xiao-Kun WangYu-Long He
Jul 20, 2021·Frontiers in Cell and Developmental Biology·Kexin LiWei Cui
Mar 23, 2021·Molecular Human Reproduction·Zhonglin CaiHongjun Li
Aug 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xiao-Fei PengWen-Chu Ye
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xiaoyu LiaoRui Liu
Sep 25, 2021·Journal of Clinical Laboratory Analysis·Jian ZhengZhaobing Qin
Dec 30, 2021·Journal of Biochemical and Molecular Toxicology·Sumei LiXiaoping Pan

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Methods Mentioned

BETA
co-immunoprecipitation
PMA
PCA

Software Mentioned

cBioPortal
m6A
VIRMA

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