Mechanism of ruminant placental lactogen action: molecular and in vivo studies

Molecular Genetics and Metabolism
A Gertler, J Djiane

Abstract

Ruminant placental lactogens (PLs) are structurally related to prolactins (PRLs) and growth hormones (GHs) and are secreted by placentae. Ruminant PLs are unusual in their capacity to bind and activate PRL and GH receptors (Rs) from other species. The present minireview summarizes several works showing that unlike in heterologous species (rat, rabbit, human), in homologous (ruminant) species, PLs act by activating PRLRs or by heterodimerizing GHRs and PRLRs, and suggests that this may be the main mechanism of PL action in vivo. Mutations impairing the ability of ovine (o)PL or bovine (b)PL to form complexes with PRLRs (but not with GHRs) do not cause loss of biological activity, because the transient existence of the homodimeric complex is still sufficient to initiate the signal transduction; however, mutants do lose their ability to activate homologous PRLRs. To explain this difference, we proposed a novel term-minimal time of homodimer persistence-which assumes that to initiate the signal transduction, a "minimal time" of homodimer existence is required for transphosphorylation of associated JAK2s. In interactions between ruminant PLs and homologous PRLRs, this minimal time is met through the interaction with homologous PRLRs...Continue Reading

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Citations

Jul 9, 2004·Reproductive Biology and Endocrinology : RB&E·Thomas E Spencer, Fuller W Bazer
Jun 27, 2013·Journal of Animal Science and Biotechnology·Fuller W Bazer
Feb 2, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Thomas E SpencerEckhard Wolf
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Jul 24, 2004·Animal Reproduction Science·E Gootwine
Jul 28, 2005·Journal of Molecular Biology·Kaare TeilumBirthe B Kragelund
Oct 20, 2011·Molecular and Cellular Endocrinology·Thomas E SpencerJustyna Filant

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