PMID: 38467Jan 1, 1978

Mechanism of S-(carboxymethylthio)cysteine cleavage by rat liver cystathionine-gamma-lyase

Physiological Chemistry and Physics
K YaoY Watanabe

Abstract

Rat liver cystathionine-gamma-lyase [L-cystathionine cysteinelyase (deaminating), EC 4.4.1.1] catalyzes the formation of pyruvic acid, ammonia, and carboxymethylhydrodisulfide from S-(carboxymethylthio)cysteine (CMTC). As judged by pyruvic acid production, the optimal pH is 8.3 in tris-HCl buffer and the Km is 2.9 mM. A possible mechanism of CMTC cleavage by cystathionase is proposed.

Related Concepts

Desmolases
Pyruvate Measurement
Lyase
Tromethamine
Cytokinesis of the Fertilized Ovum
CTH gene
Charcot-Marie-Tooth Disease, Dominant Intermediate C
Blood Ammonia Measurement
Ammonia Inhalants
Cutis Marmorata Telangiectatica Congenita

Related Feeds

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.