Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase

American Journal of Physiology. Gastrointestinal and Liver Physiology
Tomoharu ShimizuI H Chaudry

Abstract

Recent studies have shown that administration of dehydroepiandrosterone (DHEA) after trauma-hemorrhage (T-H) improves cardiovascular and hepatic function in male animals. Although androstenediol, one of the DHEA metabolites, has been recently reported to produce salutary effects on cardiac function and splanchnic perfusion after T-H, it remains unknown whether androstenediol per se has any salutary effects on hepatic function under those conditions. To study this, male Sprague-Dawley rats underwent laparotomy and approximately 90 min of hemorrhagic shock (35-40 mmHg), followed by resuscitation with four times the shed blood volume in the form of Ringer lactate. Androstenediol (1 mg/kg body wt iv) was administered at the end of resuscitation, and the animals were killed 24 h later. T-H significantly reduced portal blood flow, bile production, and serum albumin levels. Portal pressure, serum alanine aminotransferase, hepatic nitrate/nitrite, inducible nitric oxide synthase (iNOS), and endothelin-1 markedly increased after T-H. The alterations in these parameters induced by T-H were significantly attenuated in rats treated with androstenediol. Endothelial NOS (eNOS) expression, which was not different between T-H and sham, was fou...Continue Reading

References

Apr 4, 1998·The Journal of Experimental Medicine·C HierholzerD J Tweardy
Apr 29, 1998·British Journal of Pharmacology·K KauserG M Rubanyi
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Vásquez-VivarK A Pritchard
Oct 29, 1998·Biochemical and Biophysical Research Communications·M AkishitaY Ouchi
Nov 7, 1998·Molecular and Cellular Endocrinology·K P NephewS A Khan
Sep 1, 1999·Shock·C Szabó, T R Billiar
Feb 5, 2000·The Journal of Endocrinology·M SchmidtR H Straub
Sep 29, 2000·Critical Care Medicine·M K AngeleI H Chaudry
Oct 12, 2000·Biochemical and Biophysical Research Communications·S KawachiM B Grisham
Nov 9, 2000·Journal of Neuroscience Research·S W BargerP D Drew
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Scott Earley, Thomas C Resta
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·John L MershonKenneth E Clark
Mar 26, 2003·Free Radical Research·Jeannette Vásquez-VivarPavel Martásek
Apr 10, 2003·Biochemical and Biophysical Research Communications·Ho Jin YouHye Gwang Jeong
Sep 13, 2003·Resuscitation·Michelle McDonaldChristoph Thiemermann
Oct 7, 2003·Current Molecular Medicine·Tracy ChenTimothy R Billiar
Nov 14, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yukihiro YokoyamaIrshad H Chaudry
Jan 7, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julia M Orshal, Raouf A Khalil
Jan 8, 2004·European Journal of Pharmacology·Salvatore CuzzocreaChristoph Thiemermann
Aug 17, 2004·American Journal of Physiology. Endocrinology and Metabolism·Gentle ChikaniEric J Smart
Aug 18, 2004·The Journal of Surgical Research·Yukihiro YokoyamaIrshad H Chaudry

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Citations

Jun 3, 2014·European Journal of Medical Research·Philipp LichtePhilipp Kobbe
Sep 20, 2006·Resuscitation·Andreea C MarcuRoger M Loria
Dec 13, 2006·The Journal of Trauma·Rongjie YangCharles W Van Way
Dec 13, 2007·The Journal of Trauma·Andreea C MarcuRoger M Loria
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·László SzalayIrshad H Chaudry
Aug 28, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaoling LiMashkoor A Choudhry

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