Jun 1, 1974

Mechanism of silver sulfadiazine action on burn wound infections

Antimicrobial Agents and Chemotherapy
C L Fox, S M Modak


The role of silver and sulfadiazine in the mechanism of action of silver sulfadiazine on burn wound infections was investigated. Silver, but not sulfadiazine, was bound by bacteria. Sulfadiazine did not act as an antibacterial agent in low concentrations, but exhibited specific synergism in combination with subinhibitory levels of silver sulfadiazine. The efficacy of silver sulfadiazine is thought to result from its slow and steady reactions with serum and other sodium chloride-containing body fluids, which permits the slow and sustained delivery of silver ions into the wound environs. In this circumstance, a relatively minute amount of sulfadiazine appears active.

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  • Citations70

Mentioned in this Paper

Pseudomonas Infections
Serum Proteins
Staphylococcal Infections
Pseudomonas aeruginosa
Body Fluids
Silver Sulfadiazine
Sodium Chloride

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