PMID: 4365326Jul 1, 1974

Mechanism of Sindbis virus-induced intrinsic interference with vesicular stomatitis virus replication

Journal of Virology
J M Hunt, P I Marcus

Abstract

Heterologous viral interference is induced by Sindbis virus against vesicular stomatitis virus (VSV) in a manner analogous to intrinsic interference with Newcastle disease virus replication. Interference in both systems (i) depends upon early expression of the inducing virus genome, (ii) shows similar kinetics of induction, (iii) does not involve interferon action, and (iv) appears to be manifest as an all-or-none effect. VSV can be added to the list of viruses blocked by intrinsic interference. Sindbis virus-induced intrinsic interference with VSV replication is not mediated through homotypic interference by defective interfering particles; rather, T-particle and B-particle synthesis is inhibited. Significantly, intrinsic interference has no effect on primary transcription directed by the virion-associated transcriptase in VSV-challenged cells. However, Sindbis virus appears to induce interference with the VSV-RNA synthesized subsequent to primary transcription, namely, that which is dependent on protein synthesis. Thus, the target of intrinsic interference appears to be a reaction subsequent to primary transcription but prior to the appearance of protein synthesis-dependent VSV RNA, secondary transcription.

Citations

Jan 1, 1976·Archives of Virology·T A BrawnerB P Sagik
Jan 11, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Philip I Marcus
Jan 1, 1984·Journal of Interferon Research·C Svitlik, P I Marcus

Related Concepts

Centrifugation, Zonal
Kidney
Bacteriophage Plaque Assay
RNA, Viral
Kyzylagach virus
Transcription, Genetic
Tritium
Uridine
Vesicular stomatitis Indiana virus
Viral Interference

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