Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases.

The Journal of Biological Chemistry
K K ElbirtH L Bonkovsky

Abstract

Heme oxygenase-1 is an inducible enzyme that catalyzes heme degradation and has been proposed to play a role in protecting cells against oxidative stress-related injury. We investigated the induction of heme oxygenase-1 by the tumor promoter arsenite in a chicken hepatoma cell line, LMH. We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproducibly expressed in response to sodium arsenite treatment. This construct was used to investigate the role of mitogen-activated protein (MAP) kinases in arsenite-mediated heme oxygenase-1 gene expression. In LMH cells, sodium arsenite, cadmium, and heat shock, but not heme, induced activity of the MAP kinases extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. To examine whether these MAP kinases were involved in mediating heme oxygenase-1 gene expression, we utilized constitutively activated and dominant negative components of the ERK, JNK, and p38 MAP kinase signaling pathways. Involvement of an AP-1 site in arsenite induction of heme oxygenase-1 gene expression was studied. We conclude that the MAP kinases ERK and p38 are involved in the induction of heme oxygenase-1, and that at least one AP-1 element (located -...Continue Reading

References

Dec 23, 1977·Science·M D Maines, A Kappas
Feb 14, 1979·Biochemical and Biophysical Research Communications·J F SinclairH L Bonkowsky
Feb 14, 1990·Biochemical and Biophysical Research Communications·K MitaniA Kappas
Mar 10, 1990·European Journal of Biochemistry·M SatoS Shibahara
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S M Keyse, R M Tyrrell
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 1, 1983·Molecular and Cellular Biochemistry·G Kikuchi, T Yoshida
Sep 7, 1995·Annals of the New York Academy of Sciences·J D GravesE G Krebs
Oct 1, 1995·American Journal of Respiratory Cell and Molecular Biology·S L CamhiA M Choi
Nov 3, 1995·The Journal of Biological Chemistry·V AdlerZ Ronai
Jul 14, 1995·The Journal of Biological Chemistry·M Karin
Nov 1, 1994·Trends in Biochemical Sciences·H Sun, N K Tonks
Sep 23, 1994·Cell·C SachsenmaierH J Rahmsdorf
Dec 1, 1994·Molecular and Cellular Biology·H K SlussR J Davis
Jan 1, 1994·Advances in Cancer Research·D J RobbinsM H Cobb
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·G F VileR M Tyrrell
Apr 29, 1994·Biochemical Pharmacology·R W LambrechtH L Bonkovsky
Dec 15, 1993·Biochemical and Biophysical Research Communications·S van DelftR van Wijk
Feb 1, 1996·Journal of Leukocyte Biology·J C Lee, P R Young
Apr 16, 1996·Biochemical and Biophysical Research Communications·T OguroT Yoshida

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Citations

May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Fernandez, H L Bonkovsky
Aug 10, 2000·Archives of Biochemistry and Biophysics·Y ShanH L Bonkovsky
Mar 13, 2002·Archives of Biochemistry and Biophysics·Ying ShanHerbert L Bonkovsky
Jan 1, 2002·Environmental Health and Preventive Medicine·Masato Matsuoka, Hideki Igisu
Jun 1, 2013·Cell Biochemistry and Biophysics·Louis S Premkumar, Reddy M Pabbidi
Sep 18, 2007·Journal of Molecular Neuroscience : MN·Thomas StahnkeChristiane Richter-Landsberg
Aug 24, 2013·Journal of Inorganic Biochemistry·Chia-Yeh LinGuoo-Shyng W Hsu
Dec 4, 2003·Mutation Research·Gabriel Keith Harris, Xianglin Shi
Sep 11, 2002·Archives of Biochemistry and Biophysics·Pengfei GongJawed Alam
Sep 29, 2000·Biochemical Pharmacology·S Immenschuh, G Ramadori
Jan 11, 2001·Journal of Immunological Methods·K T KitchinM Suematsu
Mar 30, 2002·Critical Reviews in Oncology/hematology·Ann M Bode, Zigang Dong
Aug 6, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ansurudeen IshrathChinmoy S Dey
Sep 17, 2002·Antioxidants & Redox Signaling·Stefan W Ryter, Augustine M K Choi
Dec 17, 2005·Antioxidants & Redox Signaling·Auemduan PrawanYoung-Joon Surh
Jan 15, 2005·Antioxidants & Redox Signaling·Stefan W Ryter, Augustine M K Choi
Aug 25, 2009·Antioxidants & Redox Signaling·John D BelcherGregory Vercellotti
Jul 14, 2010·Antioxidants & Redox Signaling·Young-Myeong KimHun-Taeg Chung
Aug 4, 2006·Molecular Biology of the Cell·Michael ThorsenMarkus J Tamás
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Danielle Morse, Augustine M K Choi
Sep 23, 2006·American Journal of Respiratory Cell and Molecular Biology·Jawed Alam, Julia L Cook
Jan 13, 2012·Critical Care : the Official Journal of the Critical Care Forum·Andreas S FazekasGeorg-Christian Funk
Oct 4, 2011·Biological & Pharmaceutical Bulletin·Bin LiYoun-Chul Kim
Jul 19, 2011·Journal of Clinical Biochemistry and Nutrition·Shuyu PiaoChaekyun Kim
Sep 2, 2008·Canadian Journal of Physiology and Pharmacology·Robert T KinobeKanji Nakatsu

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