PMID: 11325071Apr 28, 2001Paper

Mechanism of sodium load-induced hypertension in non-insulin dependent diabetes mellitus model rats: defective dopaminergic system to inhibit Na-K-ATPase activity in renal epithelial cells

Hypertension Research : Official Journal of the Japanese Society of Hypertension
H TsuchidaS Owada

Abstract

Obesity-related non-insulin dependent diabetes mellitus (NIDDM) is frequently accompanied by hypertension. The present study was designed to clarify this mechanism. We first determined the blood pressure in male Wistar fatty rats (WFR), one of the NIDDM model rats, and in Wistar lean rats (WLR) as the control, with a normal (0.7% NaCl) or high (7% NaCl) salt diet. We observed no difference in systolic and mean blood pressures between WFR and WLR. WFR, however, became extremely hypertensive as a result of ingesting the high salt diet. We next investigated the mechanism for sodium sensitivity in WFR. Although the urinary excretion of dopamine (DA), a potent natriuretic factor, which reflects the ability for renal DA production, was preserved in WFR, the sodium balance with the high salt diet was positive. Moreover, Na-K-ATPase activity in isolated proximal convoluted tubules (PCT) from WFR with a normal salt diet was significantly (p<0.05) higher than that from WLR. A high salt load produced a significant (p<0.05) decrease in Na-K-ATPase activity in WLR but not in WFR. Similarly, Na-K-ATPase activity in WLR with a normal salt diet was significantly (p<0.05) inhibited by DA (10(-5) M), but this was not true in WFR. Furthermore, ur...Continue Reading

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Citations

Nov 30, 2006·Clinical and Experimental Hypertension : CHE·Anees Ahmad Banday, Mustafa F Lokhandwala
Apr 21, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S IannelloF Belfiore
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomoyasu FukuiMitsuru Adachi
Jan 6, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoriko SakumaKimio Tomita
Sep 17, 2016·Scientifica·N L Rukavina MikusicM R Choi
Jun 8, 2012·Journal of Pharmacological Sciences·Jiajie LuanRong Ma
Aug 10, 2012·Experimental Biology and Medicine·Mónica Moreira-RodriguesManuel Pestana
Apr 24, 2016·Journal of the American Heart Association·Ye ZhangWeibin Shi
Dec 7, 2002·Hypertension·Dhananjay N UmraniMustafa F Lokhandwala
Apr 6, 2007·Journal of the American Society of Nephrology : JASN·Anees Ahmad BandayMustafa F Lokhandwala
Apr 27, 2007·American Journal of Physiology. Renal Physiology·Anees Ahmad Banday, Mustafa F Lokhandwala
Aug 10, 2007·American Journal of Physiology. Renal Physiology·Swasti TiwariCarolyn A Ecelbarger
Sep 26, 2013·Molecular Medicine Reports·Li-Nan ZhangZi-Bin Gao
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Feb 22, 2012·Molecular Biology Reports·Feng-Ling WangWei Wei
May 1, 2020·Clinical and Experimental Hypertension : CHE·Hui WangGuangwei Li

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