Mechanism of spike frequency adaptation in substantia gelatinosa neurones of rat

The Journal of Physiology
Igor V MelnickB V Safronov

Abstract

Using tight-seal recordings from rat spinal cord slices, intracellular labelling and computer simulation, we analysed the mechanisms of spike frequency adaptation in substantia gelatinosa (SG) neurones. Adapting-firing neurones (AFNs) generated short bursts of spikes during sustained depolarization and were mostly found in lateral SG. The firing pattern and the shape of single spikes did not change after substitution of Ca2+ with Co2+, Mg2+ or Cd2+ indicating that Ca2+-dependent conductances do not contribute to adapting firing. Transient KA current was small and completely inactivated at resting potential suggesting that adapting firing was mainly generated by voltage-gated Na+ and delayed-rectifier K+ (KDR) currents. Although these currents were similar to those previously described in tonic-firing neurones (TFNs), we found that Na+ and KDR currents were smaller in AFNs. Discharge pattern in TFNs could be reversibly converted into that typical of AFNs in the presence of tetrodotoxin but not tetraethylammonium, suggesting that lower Na+ conductance is more critical for the appearance of firing adaptation. Intracellularly labelled AFNs showed specific morphological features and preserved long extensively branching axons, indica...Continue Reading

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Citations

Apr 14, 2007·Visual Neuroscience·Pratip Mitra, Robert F Miller
Jun 12, 2013·Nature Neuroscience·Christian PozzoriniWulfram Gerstner
Mar 4, 2010·Fiziologiia cheloveka·L V Filippova, A D Nozdrachev
Jan 16, 2008·Neural Computation·Brian Nils LundstromAdrienne L Fairhall
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fernando R Fernandez, John A White
May 10, 2005·The Journal of Physiology·G B MilesR M Brownstone
Mar 28, 2006·Biophysical Journal·P ArhemC Blomberg
May 27, 2006·Progress in Neurobiology·Robert M Brownstone
Mar 3, 2007·The Journal of Physiology·Sónia F A SantosBoris V Safronov
Aug 11, 2007·The Journal of Physiology·B A GrahamR J Callister
Jun 19, 2009·Anesthesia and Analgesia·Andrea OlschewskiMatthias Wolff
Jun 15, 2007·Journal of Neurophysiology·B A GrahamR J Callister
Feb 22, 2008·Journal of Neurophysiology·B A GrahamR J Callister
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
Feb 29, 2020·Journal of Neural Transmission·Alain ArtolaRadhouane Dallel

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