PMID: 9191670May 1, 1997Paper

Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators

The Journal of Trauma
A AyalaI H Chaudry

Abstract

Studies indicate that the liver, in particular the Kupffer cells, appear to be key contributors in the systemic inflammatory mediator response associated with shock and sepsis. Although several of these agents have been implicated as mediators of depressed immunoresponsiveness observed during sepsis, it remains unknown whether or not mediators released specifically by Kupffer cells play any significant role in producing the cellular dysfunction in distant organs. The aim of this study, therefore, was to determine whether or not acute Kupffer cell reduction before the onset of sepsis would protect splenic lymphocyte function. Kupffer cell number was reduced by prior (48 hours) treatment of mice with gadolinium chloride (GdCl2, 10 mg/kg of body weight, intravenously) or saline vehicle. Animals were then subjected to either sham-CLP (sham) or polymicrobial sepsis in the form of cecal ligation and puncture (CLP). Plasma and splenocytes were harvested at 2 or 24 hours after CLP. Splenocyte cultures were exposed to 2.5 micrograms concanavalin A/mL to assess their ability to release lymphokines. Cytokine (interleukin (IL)-2, IL-6, interferon-gamma, tumor necrosis factor-alpha) concentration in plasma or cell supernatants was assessed ...Continue Reading

References

Jan 1, 1991·The American Journal of Physiology·G BoyarskyW F Boron
Aug 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D ZhouR A Winchurch
May 17, 1991·Journal of Immunological Methods·P MiglioriniS B Corradin
Mar 1, 1991·Journal of Clinical Immunology·C L Miller-GrazianoD Catalano
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Van SnickR J Simpson
Nov 1, 1994·Archives of Surgery·P BankeyK McIntyre
Feb 1, 1995·Critical Care Medicine·S L Barriere, S F Lowry
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad

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Citations

Feb 6, 2004·Critical Care Medicine·Jacob E WangChristoph Thiemermann
Nov 16, 2004·Critical Care Medicine·Juan C Gea-BanaclocheCatherine Cordonnier
May 25, 2010·The Journal of Trauma·Daniel H SeitzMarkus W Knöferl
Jun 27, 2007·The American Journal of Pathology·Doreen E Wesche-SoldatoAlfred Ayala
Aug 29, 2006·The American Journal of Pathology·Frank HildebrandIrshad H Chaudry
Jun 18, 2004·Shock·Markus W KnöferlFlorian Gebhard
Jun 12, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fei WangAlfred Ayala
Jul 1, 2006·Current Opinion in Critical Care·Benjamin A Kohl, Clifford S Deutschman
May 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yong ChenJianping Gong
Dec 24, 2005·Shock·William J HubbardIrshad H Chaudry
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·László SzalayIrshad H Chaudry
May 25, 2001·Current Opinion in Critical Care·K Sheth, P Bankey
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline K HuAlfred Ayala
Sep 26, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcin F OsuchowskiDaniel G Remick
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heng-Fu BuXiao-Di Tan
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcin F OsuchowskiDaniel G Remick
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcin F OsuchowskiDaniel G Remick
May 26, 2004·Biochimica Et Biophysica Acta·Christian P SchneiderIrshad H Chaudry

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