Sep 1, 1977

Mechanism of the anti-inflammatory action of immunodepressants

Farmakologiia i toksikologiia
A S ZaksL G Zil'bermints

Abstract

The effectiveness of immunodepressants in lingering exudative processes, their inhibitory action in the proliferative phase of inflammation, depression of the phagocytic activity of leucocytes, as well as suppressive influence on the development of a toxic pulmonary edema and upon generalized anaphylaction reaction was demonstrated in tests staged on rats and mice. The antiphlogistic action of immunodepressants was not abolished during the first hours after their administration by specific metabolites, but was suppressed at the peak of the cytostatic effect together with the latter. The phlogolytic effect was not mediated through the hypophysis-adrenal system and did not include the lienic factor.

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Mentioned in this Paper

Pulmonary Edema
Anti-Inflammatory Agents
Cytostatic Agents
Polychemotherapy
Adrenal System
Leukocytes
Anaphylaxis
Inflammation
Phagocytosis
Granuloma

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