PMID: 11325078Apr 28, 2001Paper

Mechanism of the cardioprotective effect of inhibition of the renin-angiotensin system on ischemia/reperfusion-induced myocardial injury

Hypertension Research : Official Journal of the Japanese Society of Hypertension
L X WangK Saku

Abstract

Inhibition of the renin-angiotensin system (RAS) has been shown to be beneficial in providing cardioprotective effects in humans, but the mechanism of these effects is not well understood. In this study, we examined the effects and mechanism of RAS inhibitors on ischemia/reperfusion (IR)-induced myocardial injury in rats. Rats were randomly divided into five groups and treated with vehicle (C), angiotensin converting enzyme inhibitor (ACE-I), angiotensin II type 1 receptor antagonist (AT1-A), angiotensin II type 2 receptor antagonist (AT2-A) or ACE-I plus bradykinin B2 antagonist. Ten minutes after administration, the left main coronary artery was ligated for 45 min, and then reperfused for 120 min. IR-induced cardiomyocyte apoptosis was assessed by terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay and confirmed by typical DNA laddering. Mitogen-activated protein kinase, extracellular signal-regulated protein kinase (ERK) and c-Jun NH2-terminal protein kinase (JNK) activity in the ischemic zone were measured by an in vitro kinase assay. The duration of ventricular tachycardia (VT) during ischemia was reduced by AT2-A and ACE-I, and increased by AT1-A and ACE-I+icatibant. ACE-I and AT2-A red...Continue Reading

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Citations

Mar 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·P KossmehlD Grimm
Jul 10, 2014·Journal of Cardiovascular Translational Research·Sarah EkeløfIsmail Gögenur
Mar 8, 2007·Digestive Diseases and Sciences·Ariel U SpencerDaniel H Teitelbaum
Sep 29, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Rakesh GopinathannairJames B Martins
May 28, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kashif Kalam, Thomas H Marwick
Apr 13, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuyuki TanakaSeibu Mochizuki
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideki InadaHiroaki Matsuoka
Oct 3, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Haruhiro TokoIssei Komuro
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshiyuki YamamotoRyoji Ozono
Feb 27, 2010·American Journal of Hypertension·Maria MarketouHaralambos Gavras

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