Mechanism of the delay phenomenon: tissue protection is mediated by heme oxygenase-1

American Journal of Physiology. Heart and Circulatory Physiology
Darius KubulusMichael D Menger

Abstract

Induction of the "delay phenomenon" by chronic ischemia is an established clinical procedure, but the mechanisms conferring tissue protection are still incompletely understood. To elucidate the role of heme oxygenase-1 [HO-1 or heat shock protein-32 (HSP-32)] in delay, we examined in the skin-flap model of the ear of the hairless mouse, 1) whether chronic ischemia (delay) is capable to induce expression of HO-1, and 2) whether delay-induced HO-1 affects skin-flap microcirculation and survival by either its carbon monoxide-associated vasodilatory action or its biliverdin-associated anti-oxidative mechanism. Chronic ischemia was induced by transsection of the central feeding vessel of the ear 7 days before flap creation. The flap was finally raised by an incision through four-fifths of the base of the ear. Microcirculatory dysfunction and tissue necrosis were studied with the use of laser Doppler fluxmetry and intravital fluorescence microscopy. HO-1 protein expression was determined with Western blot analysis. Seven days of chronic ischemia (delay) induced a marked expression of HO-1. This was paralleled by a significant improvement (P <0.05) of microvascular perfusion and a reduction (P <0.05) of flap necrosis when compared wit...Continue Reading

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Citations

Sep 26, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Thomas HolzbachRiccardo E Giunta
Feb 12, 2008·The Journal of Surgical Research·Yves HarderMichael D Menger
Jan 2, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Y HarderM D Menger
Sep 27, 2005·The British Journal of Surgery·D KubulusM D Menger
Jul 31, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·M J D WagstaffD S Latchman
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Dec 3, 2016·The Journal of Craniofacial Surgery·Lei LiuZhenmin Zhao
Dec 1, 2017·Plastic and Reconstructive Surgery. Global Open·Robert P GerschAlexander B Dagum
Oct 4, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marie-Claire EdmundsDavid C Kluth
Oct 30, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Yves HarderMichael D Menger

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