May 1, 1977

Mechanism of the hypotensive action of prazosin

Archives Internationales De Pharmacodynamie Et De Thérapie
H F OatesG S Stokes

Abstract

The mechanism of action of prazosin was studied in anesthetized rats by comparison with the peripherally-acting anti-hypertensive agents, indoramin, hydralazine and diazoxide. Hydralazine and diazoxide retained full hypotensive potency after ganglionic blockade with pentolinium or alpha adrenoceptor blockade with phentolamine. Hydralzaine and diazoxide also attenuated angiotensin II pressor responses. In contrast, the hypotensive activity of prazosin was completely abolished, and that of indoramin was almost abolished by either pentolinium or phentolamine pre-treatment. Neither prazosin nor indoramin caused impairment of angiotensin II responsivity, but each was shown to possess alpha adrenoceptor blocking properties. Both agents antagonized the pressor action of norepinephrine and reversed responses to epinephrine. Thus, while hydralazine and diazoxide act directly upon the vasculature by mechanisms independent of sympathetic vasomotor tone, prazosin, like indoramin, acts as an alpha adrenoceptor blocking agent.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Z-Max
Indoramin
Diastolic Blood Pressure
Pentolinium
Norepinephrine, (+, -)-Isomer
Hydralazine
Wy-21901
Hypotensive
Epinephrine Measurement
Medihaler-Epi

About this Paper

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

The Journal of Pharmacology and Experimental Therapeutics
R M GrahamG S Stokes
Clinical and Experimental Pharmacology & Physiology
H F OatesG S Stokes
© 2020 Meta ULC. All rights reserved