PMID: 2126185May 1, 1990Paper

Mechanism of the increased ventilatory response to exercise in patients with chronic heart failure

British Heart Journal
N P Buller, P A Poole-Wilson

Abstract

Minute ventilation, respiratory rate, and metabolic gas exchange were measured continuously during maximal symptom limited treadmill exercise in 30 patients with stable chronic heart failure. The ventilatory response to exercise was assessed by calculation of the slope of the relation between minute ventilation and rate of carbon dioxide production. There was a close correlation between the severity of heart failure, determined as the maximal rate of oxygen consumption, and the ventilatory response to exercise. Reanalysis of the data after correction for ventilation of anatomical dead space did not significantly weaken the correlation but reduced the slope of the relation by approximately one third. These results show that the increased ventilatory response to exercise in patients with chronic heart failure is largely caused by mechanisms other than increased ventilation of anatomical dead space. This finding supports the concept that a significant pulmonary ventilation/perfusion mismatch develops in patients with chronic heart failure and suggests that the magnitude of this abnormality is directly related to the severity of chronic heart failure.

References

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Citations

Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·A L ClarkA J Coats
Mar 3, 1995·International Journal of Cardiology·A L ClarkA J Coats
Nov 15, 1992·Journal of the American College of Cardiology·A L ClarkA J Coats
Oct 1, 1993·Journal of the American College of Cardiology·A J Coats
Mar 1, 1996·Journal of the American College of Cardiology·T P ChuaA J Coats
May 1, 1997·The American Journal of Cardiology·G A MacGowanS Murali
Sep 29, 1998·Metabolism: Clinical and Experimental·F LeyvaA J Coats
Dec 18, 2001·International Journal of Cardiology·I DimopoulouG E Tzelepis
Oct 22, 1998·International Journal of Cardiology·W ArmourW S Hillis
Nov 1, 1996·Journal of the American College of Cardiology·A L ClarkA J Coats
Jun 1, 1997·Journal of the American College of Cardiology·T P ChuaA J Coats
Dec 31, 1997·Journal of the American College of Cardiology·T P ChuaA J Coats
Nov 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G A MacGowanS Murali
Oct 22, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Eduardo S DarzeLuis I Araujo
May 1, 1995·European Journal of Clinical Investigation·A L ClarkA J Coats
Sep 15, 2005·Heart·A L Clark
Nov 1, 1992·British Heart Journal·P DaveyP Sleight
Aug 1, 1994·British Heart Journal·A J CoatsP A Poole-Wilson
May 1, 1995·British Heart Journal·A L ClarkA N Redington
Oct 1, 1995·British Heart Journal·A P BanningR J Hall
Feb 1, 2013·Pulmonary Medicine·Anna ApostoloPiergiuseppe Agostoni

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