Mechanism of the serum thyroid hormone lowering effect of perfluoro-n-decanoic acid (PFDA) in rats

Journal of Toxicology and Environmental Health
D M GutshallA E Langley

Abstract

The mechanism and consequences of the serum thyroid hormone lowering effect of perfluorodecanoic acid (PFDA) were examined. Thyroid and pituitary gland functions in PFDA-treated rats were assessed by measuring radioiodine uptake from the circulation and the ability of the thyroid gland to secrete thyroxine (T4) and triiodothyronine (T3) in response to thyrotropin-releasing hormone (TRH) stimulation. Serum levels of reverse triiodothyronine (rT3) were measured to test for possible conversion of T4 to a biologically inactive product and the displacement of radiolabeled T4 from rat albumin in vitro by PFDA was examined. Finally, changes in activity of the thyroid hormone-sensitive liver enzymes glycerophosphate dehydrogenase (GPD) and malic enzyme (ME) in response to PFDA were analyzed. Functional activities of the thyroid and/or pituitary glands appear to be somewhat depressed by PFDA treatment. There was no increased conversion of T4 to rT3. PFDA displaced radiolabeled T4 from rat albumin with an affinity similar to thyroxine. The activities of both GPD and ME were significantly increased in livers from PFDA-treated rats. These results suggest that decreased serum levels of thyroid hormones may be due to (1) reduced responsivene...Continue Reading

References

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Citations

May 29, 2013·SAR and QSAR in Environmental Research·E PapaP Gramatica
Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Barbara PiraliLuca Chiovato
May 8, 2009·Physiology & Behavior·Michael S BloomJohn E Vena
Jul 9, 2004·Toxicology and Applied Pharmacology·Christopher LauJohn M Rogers
Mar 7, 2002·Chemico-biological Interactions·Naomi KudoYoichi Kawashima
Feb 12, 2011·Environmental Research·Emily ChanJonathan W Martin
Sep 4, 2014·Environmental Science and Pollution Research International·Francesca CoperchiniLuca Chiovato
Nov 12, 2016·Journal of Endocrinological Investigation·F CoperchiniL Chiovato
Mar 6, 2019·Journal of Cellular Biochemistry·Fengyan LiuShili Liu
May 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauJennifer Seed
Sep 15, 1999·Perceptual and Motor Skills·A E Stamps
Mar 8, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julia R VarshavskyTracey J Woodruff
Jul 3, 2009·Environmental Science & Technology·Barry C KellyFrank A P C Gobas

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