Mechanism of voltage-gated channel formation in lipid membranes

Biochimica Et Biophysica Acta
Rolando Guidelli, Lucia Becucci

Abstract

Although several molecular models for voltage-gated ion channels in lipid membranes have been proposed, a detailed mechanism accounting for the salient features of experimental data is lacking. A general treatment accounting for peptide dipole orientation in the electric field and their nucleation and growth kinetics with ion channel formation is provided. This is the first treatment that explains all the main features of the experimental current-voltage curves of peptides forming voltage-gated channels available in the literature. It predicts a regime of weakly voltage-dependent conductance, followed by one of strong voltage-dependent conductance at higher voltages. It also predicts values of the parameters expressing the exponential dependence of conductance upon voltage and peptide bulk concentration for both regimes, in good agreement with those reported in the literature. Most importantly, the only two adjustable parameters involved in the kinetics of nucleation and growth of ion channels can be varied over broad ranges without affecting the above predictions to a significant extent. Thus, the fitting of experimental current-voltage curves stems naturally from the treatment and depends only slightly upon the choice of the ...Continue Reading

References

Jun 10, 1975·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L G Gordon, D A Haydon
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·U P Fringeli, M Fringeli
Jan 1, 1991·Progress in Biophysics and Molecular Biology·M S Sansom
Feb 11, 1991·Biochimica Et Biophysica Acta·M PawlakG Schwarz
Jan 1, 1986·Annual Review of Biophysics and Biophysical Chemistry·B H HonigR F Flewelling
Jan 1, 1986·The Journal of Membrane Biology·G MenestrinaG Boheim
May 1, 1988·Biophysical Journal·I VodyanoyV Vodyanoy
May 19, 1987·Biochemistry·V RizzoG Schwarz
Jan 1, 1974·The Journal of Membrane Biology·G Boheim
Dec 31, 1973·The Journal of Membrane Biology·M EisenbergC A Mead
Oct 1, 1981·Biophysical Journal·M T Tosteson, D C Tosteson
Jan 1, 1984·Biophysical Journal·J E HallG R Marshall
Oct 1, 1983·Biophysical Journal·L J Bruner, J E Hall
Apr 1, 1983·Biophysical Journal·I VodyanoyT M Balasubramanian
Sep 20, 1997·Anesthesia and Analgesia·F Ramaioli, D De Amici
Mar 18, 2006·Biophysical Chemistry·Madhusoodanan Mottamal, Themis Lazaridis
Apr 11, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lucia Becucci, Rolando Guidelli
Jan 1, 1984·Biophysical Journal·M T Tosteson, D C Tosteson

❮ Previous
Next ❯

Citations

Sep 23, 2016·Biophysical Journal·B Scott Perrin, Richard W Pastor
Oct 13, 2016·Bioelectrochemistry·Lucia BecucciRolando Guidelli
Dec 17, 2016·Membranes·Lucia Becucci, Rolando Guidelli
Sep 22, 2017·Membranes·Christina G SiontorouStefanos K Karapetis
Aug 19, 2017·Biosensors·Carmen M González-HenríquezClaudio A Terraza
Nov 23, 2018·Biochimica Et Biophysica Acta. Biomembranes·Rolando Guidelli, Lucia Becucci
Jan 23, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Enrico ForbrigJacek Kozuch
Jun 13, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Wendong MaKai Yang
May 4, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·ZhangFei SuJacek Lipkowski
Sep 29, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Fatemeh AbbasiJacek Lipkowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved