PMID: 2106796Feb 1, 1990Paper

Mechanism underlying responses to histamine of isolated monkey and human cerebral arteries

The American Journal of Physiology
N Toda

Abstract

Cerebral artery strips obtained from Japanese monkeys partially contracted with prostaglandin F2 alpha responded to histamine with a relaxation that was attenuated by treatment with cimetidine or chlorpheniramine and was abolished by their combined treatment. Endothelium denudation suppressed the relaxation; the remaining relaxation was not influenced by the H1 antagonism but was abolished by the H2 antagonism. Treatment with methylene blue slowed the development of relaxation and, in the presence of cimetidine, depressed the magnitude of relaxation. Indomethacin did not alter the response. In the main trunk of human middle cerebral arteries obtained during autopsy, histamine predominantly caused contractions, whereas third and fifth branches responded exclusively with a dose-dependent relaxation. The contraction was abolished by chlorpheniramine, and the relaxation was attenuated by either chlorpheniramine or cimetidine. Removal of endothelium suppressed or reversed the relaxation to a contraction. It appears that the histamine-induced relaxation is mediated by endothelial H1 receptors responsible for the release of endothelium-derived relaxing factor and also by H2 receptors in smooth muscle, whereas the contraction is associ...Continue Reading

Citations

Jun 12, 1998·Japanese Journal of Pharmacology·N Toda, T Okamura
Aug 4, 2005·American Journal of Physiology. Endocrinology and Metabolism·David X ZhangWilliam B Campbell
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N I Gokina, J A Bevan
Aug 22, 2018·Frontiers in Cellular Neuroscience·Bianca N Mason, Andrew F Russo

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