PMID: 2484707Jan 1, 1989Paper

Mechanism underlying the inhibitory interaction between the nitrovasodilator SIN-1 and the endothelium

Journal of Cardiovascular Pharmacology
N A Flavahan, P M Vanhoutte

Abstract

Experiments were designed to determine the influence of the endothelium on the relaxing potency of the nitrovasodilator SIN-1. Rings of coronary arteries were suspended for isometric-tension recording in organ chambers filled with modified Krebs-Ringer bicarbonate solution, aerated with 95% O2-5% CO2 and warmed to 37 degrees C. The experiments were performed in the presence of indomethacin and propranolol in order to inhibit cyclooxygenase and beta-adrenoceptors, respectively. In rings contracted with prostaglandin F2 alpha, SIN-1 caused concentration-dependent relaxations that were increased following endothelium removal. In rings denuded of endothelium, the relaxations evoked by SIN-1 were not affected by NG-monomethyl-L-arginine (L-NMMA, which inhibits the production of endothelium-derived relaxing factor), or by superoxide dismutase and catalase (scavengers of oxygen-derived free radicals), or by L-NMMA plus superoxide dismutase and catalase. In rings with endothelium, relaxations evoked by SIN-1 were increased significantly by L-NMMA or by superoxide dismutase and catalase, and were increased further by the combination of L-NMMA plus superoxide dismutase and catalase. The difference in potency of SIN-1 between arterial rin...Continue Reading

Citations

Jan 1, 1992·British Journal of Clinical Pharmacology·T F Lüscher
Jul 1, 1992·Acta Physiologica Scandinavica·S Moncada
Feb 1, 1997·British Journal of Pharmacology·Q Liu, N A Flavahan
Aug 26, 2009·Fundamental & Clinical Pharmacology·Peyman U ErtuğErgin Singirik

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