Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease.

Biochemical Society Transactions
Joe MaltasAngeliki Malliri

Abstract

The Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types. Tiam GEFs regulate cellular migration, proliferation and survival, mainly through activating and directing Rac1 signalling. Dysregulation of the Tiam GEFs is significantly associated with human diseases including cancer, immunological and neurological disorders. Uncovering the mechanisms and consequences of dysregulation is therefore imperative to improving the diagnosis and treatment of diseases. Here we compare and contrast the subcellular localisation and function of Tiam1 and Tiam2/STEF, and review the evidence for their dysregulation in disease.

References

May 25, 1995·Nature·F MichielsJ G Collard
Aug 29, 1997·The Journal of Biological Chemistry·L E RamehL C Cantley
Dec 31, 1997·Science·P L HordijkJ G Collard
Apr 23, 1999·The Journal of Biological Chemistry·I N FlemingJ H Exton
Jan 15, 2000·The Journal of Biological Chemistry·L Y BourguignonY W Chen
Nov 15, 2001·The Journal of Biological Chemistry·Naoki MatsuoYo-ichi Nabeshima
Jul 23, 2002·Nature Cell Biology·John M LambertChanning J Der
Aug 13, 2003·The EMBO Journal·Takeshi KawauchiMikio Hoshino
Oct 11, 2003·Molecular and Cellular Neurosciences·Naoki MatsuoMikio Hoshino
Dec 17, 2003·FEBS Letters·Lars Christian HaeuslerMohammad Reza Ahmadian
May 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuan GaoYi Zheng
May 13, 2004·The Journal of Biological Chemistry·Angeliki MalliriJohn G Collard
Feb 22, 2005·Nature Cell Biology·Takashi NishimuraKozo Kaibuchi
Feb 22, 2005·Nature Cell Biology·Xinyu Chen, Ian G Macara
May 19, 2005·Molecular and Cellular Biology·Beth A ConnollyRachel J Buchsbaum
Oct 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrick A SingletonJoe G N Garcia
Oct 27, 2005·The Journal of Biological Chemistry·Angeliki MalliriJohn G Collard
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuki MiyamotoWilliam C Mobley
Jan 4, 2007·Journal of Cell Science·Ariadna Mendoza-NaranjoRicardo B Maccioni
Apr 13, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna A BirukovaKonstantin G Birukov
Aug 3, 2007·The New England Journal of Medicine·Travis DunckleyDietrich A Stephan
Oct 13, 2007·The Journal of Biological Chemistry·Adam ShutesChanning J Der
Sep 23, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Leena P DesaiChristopher M Waters
Jun 10, 2009·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Yan QiQiuhang Zhang
Nov 7, 2009·The EMBO Journal·Shin-ichi TerawakiToshio Hakoshima
Dec 17, 2009·Journal of Biomolecular Screening·Zurab SurviladzeLarry A Sklar
Jan 5, 2011·Biochemistry·Tyson R ShepherdErnesto J Fuentes
Mar 29, 2011·Human Genetics·Chunhong LiuY Eugene Yu

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Citations

Mar 25, 2021·Journal of Cell Science·Andrew P PorterAngeliki Malliri
May 1, 2021·Cells·Polly A MachinHeidi C E Welch

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