Mechanisms and consequences of positive-strand RNA virus recombination

The Journal of General Virology
Kirsten Bentley, David J Evans

Abstract

Genetic recombination in positive-strand RNA viruses is a significant evolutionary mechanism that drives the creation of viral diversity by the formation of novel chimaeric genomes. The process and its consequences, for example the generation of viruses with novel phenotypes, has historically been studied by analysis of the end products. More recently, with an appreciation that there are both replicative and non-replicative mechanisms at work, and with new approaches and techniques to analyse intermediate products, the viral and cellular factors that influence the process are becoming understood. The major influence on replicative recombination is the fidelity of viral polymerase, although RNA structures and sequences may also have an impact. In replicative recombination the viral polymerase is necessary and sufficient, although roles for other viral or cellular proteins may exist. In contrast, non-replicative recombination appears to be mediated solely by cellular components. Despite these insights, the relative importance of replicative and non-replicative mechanisms is not clear. Using single-stranded positive-sense RNA viruses as exemplars, we review the current state of understanding of the processes and consequences of re...Continue Reading

References

May 1, 1992·Journal of Virology·L MindichJ Strassman
Aug 1, 1991·Journal of Virology·B G Weiss, S Schlesinger
Nov 1, 1989·The Journal of General Virology·P J HughesG Stanway
Mar 1, 1986·Journal of Virology·S MakinoM M Lai
Nov 7, 1986·Cell·K Kirkegaard, D Baltimore
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C S HahnJ H Strauss
Apr 1, 1974·The Journal of General Virology·P D CopperD Delong
Feb 3, 1995·Journal of Molecular Biology·C D CarpenterA E Simon
Aug 15, 1997·Structure·J L HansenS C Schultz
Jan 1, 1997·Annual Review of Microbiology·E Domingo, J J Holland
Jul 29, 1998·The Journal of General Virology·W BarclayD J Evans
May 20, 1999·Molecular Biology and Evolution·E C HolmesA Rambaut
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·M WorobeyE C Holmes
Oct 9, 1999·Journal of Virology·A P GmylV I Agol
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·M Negroni, H Buc
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·M J Kim, C Kao

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Citations

Jun 18, 2020·Veterinary Research·Georges SaadeFrançois Meurens
Nov 5, 2020·Molecular Biology and Evolution·Yiyan YangXiaofang Jiang
Feb 15, 2021·Archives of Virology·J E Libbey, R S Fujinami
Apr 12, 2021·Biochemistry. Biokhimii︠a︡·Alexey A Agranovsky
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bara CihlovaJan Silhan
Aug 3, 2021·Virus Research·Filipa F ValeJoao Goncalves

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