Mechanisms and functions of p38 MAPK signalling

The Biochemical Journal
Ana Cuadrado, Angel R Nebreda

Abstract

The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by generating a plethora of different biological effects. The diversity and specificity in cellular outcomes is achieved with an apparently simple linear architecture of the pathway, consisting of a core of three protein kinases acting sequentially. In the present review, we dissect the molecular mechanisms underlying p38 MAPK functions, with special emphasis on the activation and regulation of the core kinases, the interplay with other signalling pathways and the nature of p38 MAPK substrates as a source of functional diversity. Finally, we discuss how genetic mouse models are facilitating the identification of physiological functions for p38 MAPKs, which may impinge on their eventual use as therapeutic targets.

Associated Clinical Trials

References

Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·C LechnerA Ullrich
Feb 17, 2000·Cellular Signalling·K Ono, J Han
Jun 6, 2000·Trends in Biochemical Sciences·A R Nebreda, A Porras
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·J S MudgettM M Shen
Sep 30, 2000·The Journal of Biological Chemistry·G AlonsoA R Nebreda
Dec 4, 2001·Biology of the Cell·H Enslen, R J Davis
Dec 18, 2001·Nature Immunology·Simona SaccaniGioacchino Natoli
Mar 16, 2002·Nature Structural Biology·Christopher PargellisJohn Regan
Nov 28, 2002·Biological Chemistry·Yu Shi, Matthias Gaestel
Dec 17, 2002·Molecular and Cellular Biology·Concetta AmbrosinoAngel R Nebreda
Jan 11, 2003·The Journal of Biological Chemistry·Arun P ChopraNicholas S Duesbery
Feb 26, 2003·The Biochemical Journal·Ricardo M Biondi, Angel R Nebreda
Aug 2, 2003·Genes & Development·Deborah BranchoRoger J Davis
Sep 3, 2003·Nature Reviews. Drug Discovery·Sanjay KumarJohn C Lee
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Deborah K Morrison, Roger J Davis

❮ Previous
Next ❯

Citations

Mar 30, 2013·Breast Cancer Research and Treatment·Heather M MooreCelina G Kleer
Apr 13, 2011·Cell Research·Adem KalenderGeorge Thomas
Feb 2, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Martina KluthSarah Minner
Jun 4, 2013·Nature Cell Biology·Christian C Dibble, Brendan D Manning
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ivan del Barco BarrantesAngel R Nebreda
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Joana A ZulaAnette H H van Boxel-Dezaire
Nov 4, 2010·The Journal of Biological Chemistry·Seung-Hoon LeeJong-Bok Yoon
Mar 7, 2012·The Journal of Biological Chemistry·Estelle Toulme, Baljit S Khakh
Mar 10, 2011·Tissue Engineering. Part a·Rania El BacklyMaddalena Mastrogiacomo
Nov 13, 2012·Nucleic Acids Research·Stella TommasiAhmad Besaratinia
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yaneth Castro-CoronelEsther López-Bayghen
Mar 16, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Serena Banh, Barbara F Hales
Mar 20, 2012·Genes & Development·Gianpiero SpedaleW W M Pim Pijnappel
Sep 15, 2011·Pigment Cell & Melanoma Research·Pablo Lopez-Bergami
Sep 23, 2011·Journal of Virology·Timothy Q CrawfordJason D Barbour
Feb 6, 2013·Molecular and Cellular Biology·Kirsty F MacKenzieJ Simon C Arthur
Sep 21, 2011·Molecular and Cellular Biology·Srikripa ChandrasekaranJeanette Gowen Cook
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Marie Cargnello, Philippe P Roux
Jan 3, 2013·The Journal of Clinical Investigation·Paolo E PorporatoAndrea Graziani
Nov 29, 2012·The Journal of Clinical Investigation·Yael G AlevyMichael J Holtzman
Mar 13, 2012·Cell Communication and Signaling : CCS·Dagmar FaustCornelia Dietrich
Nov 1, 2011·Cell Communication and Signaling : CCS·Jens RauchWalter Kolch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Signal Transduction
Ana Risco, Ana Cuenda
Trends in Molecular Medicine
Lydia R CoulthardSusan A Burchill
© 2021 Meta ULC. All rights reserved