Mechanisms and mediators of nasal symptoms in non-allergic rhinitis

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R J SalibP H Howarth

Abstract

Non-allergic rhinitis may be a contributing factor in up to 60% of rhinitis patients and a sole contributor in a quarter. It is a highly heterogeneous condition with poorly understood pathophysiological mechanisms. Compelling evidence is emerging of a localized nasal mucosal allergic response in some non-allergic rhinitic subjects in the absence of systemic atopy. While the inflammatory disease pathway in non-allergic rhinitis may share some of the features of its allergic counterpart, overall the mechanisms remain unclear, and there are likely to be differences. In particular, symptoms of nasal congestion and rhinorrhoea tend to be more prominent and persistent in non-allergic rhinitic patients compared with allergic rhinitis. Our aim is to review the literature relating to mechanisms and mediators of nasal symptoms in non-allergic rhinitis. Better understanding of the underlying pathophysiological basis should enable the development of more accurate testing, and better targeted therapeutic options in the future.

References

Jan 1, 1977·Acta Oto-laryngologica·L Malm
Mar 1, 1979·The Annals of Otology, Rhinology, and Laryngology·A Konno, K Togawa
Jan 1, 1976·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·H H Toppozada, M A Talaat
Nov 1, 1992·Journal of Applied Physiology·J N BaraniukP J Barnes
Jan 1, 1992·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·C R BaumgartenG Kunkel
Mar 1, 1991·American Journal of Respiratory Cell and Molecular Biology·J N BaraniukM A Kaliner
Sep 1, 1991·The American Review of Respiratory Disease·G BraunsteinN Frossard
Sep 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J S LacroixJ M Lundberg
Oct 1, 1991·The American Review of Respiratory Disease·P E ChristieT H Lee
Sep 1, 1990·The Journal of Clinical Investigation·J N BaraniukM A Kaliner
Apr 1, 1990·The Journal of Clinical Investigation·J N BaraniukM Kaliner
Oct 1, 1985·The Journal of Clinical Investigation·A G TogiasL M Lichtenstein
Mar 1, 1988·The American Review of Respiratory Disease·G SilberP Eggleston
Jan 1, 1989·The Journal of Allergy and Clinical Immunology·G RaphaelM Kaliner
Dec 1, 1987·The American Review of Respiratory Disease·J M LundbergA Anggård
Feb 1, 1987·Archives of Otolaryngology--head & Neck Surgery·B OstbergN Mygind
Sep 1, 1987·The Journal of Allergy and Clinical Immunology·J DolovichF Kazim
May 1, 1988·The Journal of Allergy and Clinical Immunology·A TogiasL M Lichtenstein
Jan 1, 1985·New England and Regional Allergy Proceedings·G A Settipane, D E Klein
Jul 1, 1985·The Journal of Clinical Investigation·C R BaumgartenD Proud
Jun 1, 1970·The Annals of Otology, Rhinology, and Laryngology·N Cauna
Dec 1, 1968·The Annals of Otology, Rhinology, and Laryngology·L J Hall, R T Jackson
Feb 1, 1980·The Journal of Allergy and Clinical Immunology·M F MullarkeyD R Webb
Jan 1, 1983·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·S S Elwany, W M Stephanos
Nov 1, 1983·The Journal of Clinical Investigation·D ProudL M Lichtenstein
Apr 1, 1981·The Journal of Allergy and Clinical Immunology·R L JacobsR N Boswell
May 1, 1994·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·P Graf, J E Juto
Jan 1, 1995·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·H M BlomE Rijntjes
Oct 1, 1995·The Journal of Allergy and Clinical Immunology·D L HamilosQ Hamid
Jan 1, 1995·Acta Oto-laryngologica. Supplementum·N MoriK Yajin
Dec 1, 1993·The American Review of Respiratory Disease·E IsraelJ M Drazen

❮ Previous
Next ❯

Citations

Aug 13, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hong WangHua Hu
Jul 29, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jennifer DereberyRichard Stanford
Dec 7, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery·Christos Georgalas, Ljiljana Jovancevic
Feb 26, 2010·Clinical and Molecular Allergy : CMA·Cyrus H NozadChristie F Michael
May 15, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Jayant M Pinto, Seema Jeswani
Mar 12, 2013·TheScientificWorldJournal·Ming-Ying LanChih-Hung Shu
Dec 29, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kivanc GunhanMurat Songu
May 6, 2010·Expert Review of Clinical Immunology·Harumi Jyonouchi
Oct 4, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kaiser G LimEric Moore
Dec 2, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T Groot KormelinkF A Redegeld
Jan 10, 2009·Allergy·J BousquetH-U Simon
May 25, 2013·International Forum of Allergy & Rhinology·Hille SuojalehtoHarri Alenius
Jul 21, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D G PoweN S Jones
Dec 17, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P CampoM Blanca
Apr 17, 2016·Immunology and Allergy Clinics of North America·Nikolaos G Papadopoulos, George V Guibas
Apr 13, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Woo-Jung SongYoon-Seok Chang
Apr 3, 2012·Pharmacology & Therapeutics·Stanislas Grassin-DelylePhilippe Devillier
Apr 23, 2015·Current Opinion in Allergy and Clinical Immunology·Kari R Brown, Jonathan A Bernstein
Dec 17, 2009·Current Opinion in Allergy and Clinical Immunology·Carmen RondónMiguel Blanca
Aug 5, 2016·The Journal of Laryngology and Otology·T MarshakR J Harvey
Sep 29, 2012·International Archives of Allergy and Immunology·Ayşe Baççıoğlu KavutPinar Atasoy
Jun 18, 2009·Seminars in Immunopathology·Stephan C Bischoff
Jun 4, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Silvia TriaricoAntonio Ruggiero
Jul 10, 2018·Clinical and Translational Allergy·C BachertP Hellings
Jan 1, 2016·Allergy & Rhinology·Maria LaurielloMarco Fusetti
Dec 23, 2009·Current Opinion in Allergy and Clinical Immunology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R M Naclerio
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
R A Settipane, P Lieberman
© 2021 Meta ULC. All rights reserved