Mechanisms and possible controls of the in utero Zika virus infection: Where is the Holy Grail?

American Journal of Reproductive Immunology : AJRI
Kazumasa Fuwa, Satoshi Hayakawa

Abstract

Zika virus infection (ZVI) is a great concern for human health because it frequently causes fetal anomalies. Little is known about pathophysiology of ZVI because it has been regarded as a mild, no life-threatening infection. However, the latest endemic in South and Central America took attention of perinatologists, microbiologists, and pathologists. Both in vivo and in vitro studies suggest neurotropic nature of Zika virus but do not clarify viral kinetics during vertical transmissions. In this review, we focus on the clinical and microbiological natures ZVI for pregnant women especially how placental barriers are broken down.

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Related Concepts

Zika Virus Disease (Disorder)
Zika virus (organism)
Metazoa
Nervous System Structure
Placenta
Pregnancy Complications, Infectious
Uterus
Maternal-Fetal Infection Transmission
Endemic Diseases
Viral Tropism

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