Mechanisms and regulation of DNA end resection.

The EMBO Journal
Maria Pia LongheseMichela Clerici

Abstract

DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, because failure to repair these lesions can lead to genomic instability. DSBs can arise accidentally at unpredictable locations into the genome, but they are also normal intermediates in meiotic recombination. Moreover, the natural ends of linear chromosomes resemble DSBs. Although intrachromosomal DNA breaks are potent stimulators of the DNA damage response, the natural ends of linear chromosomes are packaged into protective structures called telomeres that suppress DNA repair/recombination activities. Although DSBs and telomeres are functionally different, they both undergo 5'-3' nucleolytic degradation of DNA ends, a process known as resection. The resulting 3'-single-stranded DNA overhangs enable repair of DSBs by homologous recombination (HR), whereas they allow the action of telomerase at telomeres. The molecular activities required for DSB and telomere end resection are similar, indicating that the initial steps of HR and telomerase-mediated elongation are related. Resection of both DSBs and telomeres must be tightly regulated in time and space to ensure genome stability and cell survival.

References

Jan 1, 1989·Molecular and Cellular Biology·E R Henderson, E H Blackburn
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·S Keeney, N Kleckner
May 3, 1996·Cell·R J WellingerV A Zakian
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·G Barnes, D Rio
May 23, 1998·Science·S GravelR J Wellinger
May 10, 2000·Current Biology : CB·S MarcandE Gilson
Jun 30, 2001·Molecular Cell·T UsuiJ H Petrini
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chunyan LiuHoward A Nash
Mar 26, 2003·Cell·Susan K Amundsen, Gerald R Smith
Jun 7, 2003·Science·Lee Zou, Stephen J Elledge
Aug 19, 2003·Genes & Development·Daisuke NakadaKatsunori Sugimoto
Oct 24, 2003·Nature·Jeffrey A UbersaxDavid O Morgan
May 4, 2004·Molecular and Cellular Biology·Enrico BaroniMaria Pia Longhese
Jun 17, 2004·Genes & Development·Michel LarrivéeRaymund J Wellinger
Oct 16, 2004·Molecular and Cellular Biology·Kazunori TomitaMasaru Ueno

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Citations

Jun 1, 2012·Human Gene Therapy·Helen FosterGeorge Dickson
Jun 25, 2013·Human Gene Therapy·Linda PopplewellGeorge Dickson
Jan 12, 2011·Journal of Experimental Botany·Bernd Edlinger, Peter Schlögelhofer
Jun 5, 2013·Cold Spring Harbor Perspectives in Biology·Christopher J WebbVirginia A Zakian
Mar 3, 2011·Genes & Development·Sophie E Polo, Stephen P Jackson
Feb 23, 2012·Molecular and Cellular Biology·Marina MartinaMaria Pia Longhese
Oct 15, 2011·PloS One·Sergei BoichukOle V Gjoerup
Oct 15, 2013·Chromosoma·Diego BonettiMaria Pia Longhese
Oct 26, 2013·International Journal of Cell Biology·Silvia C LenzkenSilvia M L Barabino
Jan 8, 2014·Nucleic Acids Research·Emilie FalletMaria Teresa Teixeira
May 27, 2014·Cellular and Molecular Life Sciences : CMLS·Ting Liu, Jun Huang
Nov 16, 2011·Cellular and Molecular Life Sciences : CMLS·Karen FinnMuriel Grenon
Oct 27, 2011·Seminars in Cell & Developmental Biology·Torben R Kasparek, Timothy C Humphrey
Oct 23, 2015·Cell Reports·Feng ZhangXiaochun Yu
Apr 4, 2013·Scientific Reports·Azadeh AryanZach N Adelman
Feb 15, 2013·Scientific Reports·Tomoji MashimoTadao Serikawa
Oct 13, 2011·The New Phytologist·Wanda M WaterworthChristopher E West
Mar 4, 2011·The New Phytologist·Kim OsmanF Chris H Franklin
Oct 7, 2011·Journal of Cellular and Molecular Medicine·Alyssa A SprouseBrittney-Shea Herbert
Aug 27, 2013·Cell Cycle·Lykourgos-Panagiotis ZalmasNicholas B La Thangue
May 28, 2013·Cell Cycle·Magda GranataMarco Muzi-Falconi
Apr 23, 2013·Journal of Molecular Biology·Camilla TrovesiMaria Pia Longhese
May 7, 2016·Acta Biochimica Et Biophysica Sinica·Ting Liu, Jun Huang
May 14, 2016·Acta Biochimica Et Biophysica Sinica·Sharad C Paudyal, Zhongsheng You
Apr 23, 2016·Expert Opinion on Therapeutic Patents·Ruo-Jun ManHai-Liang Zhu
Jun 1, 2016·Genomics, Proteomics & Bioinformatics·Ting Liu, Jun Huang
Oct 26, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Akihisa TakahashiTakeo Ohnishi
Feb 6, 2017·The Plant Journal : for Cell and Molecular Biology·Takeshi HirakawaSachihiro Matsunaga
Mar 1, 2018·Extremophiles : Life Under Extreme Conditions·Mariarosaria De FalcoMariarita De Felice

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