Mechanisms and regulation of intestinal uptake and transfer of iron

Acta Paediatrica Scandinavica. Supplement
P R Flanagan

Abstract

Despite much research over the past fifty years, the precise details of intestinal iron absorption remain unclear. The lack of understanding extends both to the specific biochemical mechanisms of transport as well as the means by which these are regulated. Iron in several dietary forms must be digested and processed in the intestinal lumen, taken up across the mucosal brush border membrane, transported through the intestinal absorptive cell, accomplish a second transmembrane passage across the basolateral membrane and, finally, be transported to sites of iron metabolism and storage within the body. Recent findings in several of these areas are reviewed. Evidence is presented to support the involvement, or non-involvement, of several intestinal iron-binding components in iron transport. In the future, the application of molecular biology to the investigation of intestinal iron metabolism will undoubtedly increase understanding of absorption mechanisms and their regulation.

References

Jul 1, 1979·Scandinavian Journal of Haematology·R GräsbeckR Tenhunen
Dec 15, 1977·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F A El-Shobaki, W Rummel
Oct 1, 1976·British Journal of Haematology·J W HallidayU Mack
Jan 1, 1975·The American Journal of Physiology·M C LinderH N Munro
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·S J Fairweather-Tait
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·J H Brock
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P C AdamsJ W Halliday
Jan 1, 1989·The Journal of Clinical Investigation·P WhittakerJ D Cook
Dec 19, 1985·Biochimica Et Biophysica Acta·J MazurierG Spik
Sep 8, 1988·Biochimica Et Biophysica Acta·L R PurvesP Jacobs
Apr 1, 1987·European Journal of Clinical Investigation·W StremmelG Strohmeyer
Jul 10, 1987·Biochimica Et Biophysica Acta·K B RajaT J Peters
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C SibilleP Aisen
Dec 1, 1987·Pediatric Research·S J Fairweather-TaitM J Minski
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R L IdzerdaG S McKnight
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C M CravenJ Kaplan
Jan 20, 1987·Biochimica Et Biophysica Acta·K B RajaT J Peters
Jan 1, 1987·British Journal of Haematology·K R OsterlohT J Peters
Apr 9, 1987·Biochimica Et Biophysica Acta·R J Simpson, T J Peters
Mar 27, 1986·Biochimica Et Biophysica Acta·R J Simpson, T J Peters
Nov 22, 1985·Biochimica Et Biophysica Acta·G JohnsonL R Purves
Aug 1, 1969·Experimental Cell Research·H L Webster, D D Harrison
Nov 1, 1974·Acta Medica Scandinavica·B J de Vet, J van Gool
Dec 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·M Worwood, A Jacobs
Sep 1, 1970·British Journal of Haematology·G M BernierM E Conrad
Jan 18, 1982·Biochimica Et Biophysica Acta·R GräsbeckR Tenhunen
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A Dautry-VarsatH F Lodish
May 16, 1984·Biochimica Et Biophysica Acta·R J Simpson, T J Peters
May 1, 1983·The Journal of Clinical Investigation·G JohnsonL R Purves
Jul 1, 1980·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·E H Morgan
Oct 1, 1962·The Journal of Clinical Investigation·A TURNBULLC A FINCH
Apr 1, 1965·The Journal of Clinical Investigation·R W CHARLTONT H BOTHWELL

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Citations

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·C E Carpenter, A W Mahoney
Aug 31, 2004·The Journal of Nutrition·Chi Kong YeungDennis D Miller
Jan 7, 2011·Metallomics : Integrated Biometal Science·Okhee Han
Jan 1, 1997·Annual Review of Nutrition·R A Goyer
Apr 1, 1991·Digestive Diseases and Sciences·J GolubovP Adams
Feb 11, 2005·Journal of Occupational Health·Kiran Kalia, Swaran J S Flora

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