Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.

Nature Reviews. Rheumatology
Philip R CoryellR F Loeser

Abstract

The development of osteoarthritis (OA) correlates with a rise in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been implicated in cartilage degradation and OA. Age-related mitochondrial dysfunction and associated oxidative stress might induce senescence in joint tissue cells. However, senescence is not the only driver of OA, and the mechanisms by which senescent cells contribute to disease progression are not fully understood. Furthermore, it remains uncertain which joint cells and SASP-factors contribute to the OA phenotype. Research in the field has looked at developing therapeutics (namely senolytics and senomorphics) that eliminate or alter senescent cells to stop disease progression and pathogenesis. A better understanding of how senescence contributes to joint dysfunction may enhance the effectiveness of these approaches and provide relief for patients with OA.

References

Jun 1, 1991·Environmental Health Perspectives·R Sager
Jun 1, 1991·Seminars in Arthritis and Rheumatism·J P PelletierJ Martel-Pelletier
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Oct 12, 1995·The New England Journal of Medicine·A M GoldsteinW H Clark
May 21, 1997·Journal of the National Cancer Institute·A M Goldstein, M A Tucker
Jan 7, 1998·Experimental Cell Research·M Serrano
Jul 23, 2003·The Journal of Biological Chemistry·Gil BlanderLeonard Guarente
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD
Nov 3, 2004·The Journal of Clinical Investigation·Janakiraman KrishnamurthyNorman E Sharpless
Jan 11, 2005·Osteoarthritis and Cartilage·Alfons S K de HoogeWim B van den Berg
Oct 29, 2005·Arthritis and Rheumatism·Elizabeth ReganJames Crapo
Dec 31, 2005·Arthritis and Rheumatism·Jennifer M Hootman, Charles G Helmick
Apr 22, 2006·Aging Cell·Bo Yun LeeEun Seong Hwang
Jan 25, 2008·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Susan J Keam
Oct 3, 2008·Cancer Research·Brian D LehmannDavid M Terrian
Jan 19, 2010·Annual Review of Pathology·Jean-Philippe CoppéJudith Campisi
Feb 18, 2010·Molecular Systems Biology·João F PassosThomas von Zglinicki
May 28, 2010·Arthritis and Rheumatism·Martin K LotzDarryl D'Lima
Jun 1, 2010·Annals of the Rheumatic Diseases·Jenny L ScottDavid A Young
Oct 23, 2010·Molecular Cell·Guido KroemerBeth Levine
Nov 26, 2010·Current Opinion in Genetics & Development·Judith Campisi
Nov 16, 2011·Annals of the Rheumatic Diseases·Beatriz CaramésMartin Lotz
Feb 11, 2012·Aging Cell·Glyn NelsonThomas von Zglinicki
Mar 7, 2012·Arthritis and Rheumatism·Richard F LoeserMary B Goldring
Jun 19, 2012·The Journal of Clinical Investigation·Jeremy S TilstraPaul D Robbins
Nov 13, 2012·Annual Review of Physiology·Judith Campisi
Jan 10, 2013·Arthritis Research & Therapy·Meina WangDi Chen
Mar 5, 2013·The Journal of Clinical Investigation·Tamara TchkoniaJames L Kirkland
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·James W GodwinNadia A Rosenthal
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Sep 5, 2013·International Journal of Molecular Sciences·Krishnan VenkataramanT C Tai
Nov 13, 2013·Nucleic Acids Research·Marita G OverhoffCleo L Bishop

❮ Previous
Next ❯

Citations

Feb 11, 2021·Pharmaceuticals·Oliver McClurgLinda Troeberg
Feb 21, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yang ChenBin Shen
Apr 4, 2021·Antioxidants·Yohei SanadaShigeru Miyaki
May 4, 2021·Frontiers in Pharmacology·Xiaoyan CaiChanghai Ding
May 5, 2021·European Journal of Histochemistry : EJH·Nikolajs Sjakste, Una Riekstiņa
Jul 6, 2021·Frontiers in Pharmacology·Yuchen HeHang Lin
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ange Mouithys-MickaladAman Paul
Aug 21, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Junchao LuoQing Bi
Aug 31, 2021·The EMBO Journal·Daniel J KlionskyFederico Pietrocola
Sep 2, 2021·Nature Reviews. Rheumatology·Armaghan MahmoudianFrank P Luyten
Aug 27, 2021·Journal of Pineal Research·Ko-Hsiu LuShun-Fa Yang
Sep 12, 2021·Bone Research·Mei WanJennifer H Elisseeff

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
amputation

Software Mentioned

SASP Atlas

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Aging Cell
Kendal McCullochTaranjit Singh Rai
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Jinwei XieXijie Yu
Best Practice & Research. Clinical Rheumatology
A Shane Anderson, R F Loeser
© 2021 Meta ULC. All rights reserved