Mechanisms and Treatment of Intradialytic Hypertension

Blood Purification
Peter N Van Buren, Jula K Inrig

Abstract

Intradialytic hypertension is a condition where there is an increase in blood pressure (BP) from pre- to post-hemodialysis; this condition has been recently identified as an independent mortality risk factor in hypertensive hemodialysis patients. The mechanisms and management of intradialytic hypertension have been explored in numerous research studies over the past few years. Patients with intradialytic hypertension have been found to be more chronically volume overloaded compared to other hemodialysis patients, although no causal role has been established. Patients with intradialytic hypertension have intradialytic vascular resistance surges that likely explain the BP increase during dialysis. Acute intradialytic changes in endothelial cell function have been proposed as etiologies for the increase in vascular resistance, although it is unclear if endothelin-1 or some other vasoconstrictive peptide is responsible. There is an association between dialysate to serum sodium gradients and BP increase during dialysis in patients with intradialytic hypertension, although it is unclear if this is related to endothelial cell activity or acute osmolar changes. In addition to probing the dry weight of patients with intradialytic hypert...Continue Reading

Citations

Mar 7, 2017·Seminars in Dialysis·Dana C Miskulin, Daniel E Weiner
Mar 28, 2018·Clinical and Experimental Hypertension : CHE·Takayasu ItoMasaaki Ito
Dec 1, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anna Meyring-WöstenPeter Kotanko
Oct 17, 2018·Clinical and Experimental Hypertension : CHE·Lu-Xi Zou, Ling Sun
Mar 9, 2019·Hemodialysis International·Jenny StenbergHans Furuland
Jun 1, 2018·International Journal of Hypertension·Vaia D Raikou, Despina Kyriaki
Aug 1, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kiyotaka UchiyamaHiroshi Itoh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.