Mechanisms associated with the effects of urea on the micellar structure of sodium dodecyl sulphate in aqueous solutions

Progress in Biophysics and Molecular Biology
Yanis R EspinosaC Gastón Ferrara

Abstract

We used simulations by Molecular Dynamics to characterize the mechanism whereby the variations in the urea concentration modifies the micellar structure of sodium dodecyl sulfate monomers in water. From a self-assembled micellar system, we observed that increasing urea concentration leads to a decrease in aggregation number. Likewise, when increasing urea concentration, the micelles increase their nonpolar surface exposed to solvent, while the polar surface exposed to solvent decreases. This rearrangement process of SDS micelles in presence of urea is mainly due to the fact that the ions of Na+ that stabilize the micellar structure increase its interaction with urea. In this process, the SDS hydrophilic head and Na+ ions increases its solvation by urea, destabilizing micellar structure and exponing the hydrophobic core to the solvent.

Citations

Jul 5, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Santosh L GawaliPuthusserickal A Hassan

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