Mechanisms Behind Blood Flow-Restricted Training and its Effect Toward Muscle Growth

Journal of Strength and Conditioning Research
Paul S Hwang, Darryn S Willoughby

Abstract

Hwang, P and Willoughby, DS. Mechanisms behind blood flow-restricted training and its effect toward muscle growth. J Strength Cond Res 33(7S): S167-S179, 2019-It is widely established throughout the literature that skeletal muscle can induce hypertrophic adaptations after progressive overload of moderate-to-high-intensity resistance training. However, there has recently been a growing body of research that shows that the combination of blood flow-restricted (BFR) training with low-intensity resistance exercise can induce similar gains in muscular strength and hypertrophic adaptations. The implementation of external pressure cuffs over the most proximal position of the limb extremities with the occlusion of venous outflow of blood distal to the occlusion site defines the BFR training protocol. There are various mechanisms through which BFR training may cause the stimulations for skeletal muscle hypertrophy and increases in strength. These may include increases in hormonal concentrations, increases within the components of the intracellular signaling pathways for muscle protein synthesis such as the mTOR pathway, increases within biomarkers denoting satellite cell activity and apparent patterns in fiber type recruitment. There ha...Continue Reading

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