PMID: 2096384Nov 1, 1990Paper

Mechanisms behind the relaxing effect of furosemide on the isolated rabbit ear artery

Pharmacology & Toxicology
R TianF Andreasen

Abstract

The effect of furosemide on isometric contraction and 86Rb uptake were studied in the isolated rabbit central ear artery (CEA). A concentration-dependent relaxing effect of furosemide (0.06 mM-1.0 mM) was found in vessel segments with intact endothelium. The maximal relaxation was 28.6 +/- 3.9% (10). The effect was not diminished in segments deprived of endothelium, and removal of endothelium itself caused no change of the force development to electrical field stimulation. The relaxing effect was time-dependent and stimulation-dependent and was not significantly affected by membrane depolarization induced by increasing external [K+] from 10 to 120 mM. The 86Rb uptake was inhibited by both furosemide and ouabain (8.0 +/- 0.5(8) and 5.3 +/- 0.5(8) versus 12.8 +/- 0.9(16) nmol (K+).mm-1.(10 min.)-1 in the furosemide (1.0 mM), ouabain (1.0 mM) and control groups, respectively) without interaction between the two drugs. The 86Rb uptake was not further inhibited by increasing the furosemide concentration from 0.12 mM to 1.0 mM. Our results suggest: firstly, the direct relaxing effect of furosemide on isolated vessel segments is endothelium-independent and secondly, the inhibition of the Na(+)-K(+)-Cl- cotransport and a possible conse...Continue Reading

References

Aug 1, 1977·The Journal of General Physiology·G DroogmansR Casteels
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·J F GerkensA J Smith
Nov 1, 1988·Pharmacology & Toxicology·F Andreasen, J H Christensen
Jan 1, 1984·Annual Review of Pharmacology and Toxicology·R F Furchgott
Oct 1, 1984·British Journal of Pharmacology·J F Gerkens, A J Smith
Oct 1, 1983·The Journal of Physiology·C Aalkjaer, M J Mulvany
Oct 1, 1982·Biopharmaceutics & Drug Disposition·M M Hammarlund, L K Paalzow
Jul 17, 1981·European Journal of Pharmacology·V A KreyeI Villhauer

❮ Previous
Next ❯

Citations

Nov 18, 2000·British Journal of Pharmacology·F PourageaudJ L Freslon
Jan 12, 2010·Current Opinion in Nephrology and Hypertension·Sergei N OrlovPavel Hamet
May 18, 1999·Pharmacology & Toxicology·J S Petersen
Jan 20, 2009·Biochemical and Biophysical Research Communications·Svetlana V KoltsovaSergei N Orlov
Jun 27, 2015·Genes & Diseases·Sergei N OrlovNickolai O Dulin
Aug 12, 2016·Physiology·Ebbe BoedtkjerChristian Aalkjaer
Jan 22, 2010·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Alex Luiz Pozzobon PereiraWilson Roberto Poi
May 19, 2001·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·M D Sousa-NetoJ D Pécora
Jun 25, 2010·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Jaime A DíazBelén E Fernández
Nov 9, 2006·American Journal of Physiology. Renal Physiology·Xuemei WangRodger Loutzenhiser
Jan 30, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Puneet GargW Charles O'Neill
Dec 23, 1998·British Journal of Clinical Pharmacology·F StankeG Bessard
Feb 26, 2016·American Journal of Physiology. Renal Physiology·Xiaohua HuangBranko Braam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.