Mechanisms by which angiotensin II affects the heart rate of the conscious sheep

Circulation Research
W B LeeE R Lumbers

Abstract

Intravenous infusions of angiotensin II were given to conscious sheep. During these infusions, the pressor action of angiotensin was antagonized by concomitant infusion of sodium nitroprusside. Under these conditions, angiotensin produced a dose-dependent tachycardia. This dose-dependent tachycardia was not affected by propranolol and therefore it was not due to an action of angiotensin on sympathoadrenal mechanisms. The dose-dependent tachycardia was reduced by atropine, and abolished by increases in systolic pressure. We conclude that iv infusions of angiotensin cause a central, dose-dependent reduction in vagal tone. This action is normally antagonized by the baroreceptor reflex response to the hypertensive action of angiotensin. Therefore, in those conditions in which endogenous angiotensin production is increased and blood pressure is not elevated (e.g., sodium deficiency and pregnancy), angiotensin may influence heart rate.

References

Aug 1, 1967·British Journal of Pharmacology and Chemotherapy·J Staszewska-Barczak, J R Vane
Aug 1, 1970·Clinical Science·M D Joy, R D Lowe
Mar 1, 1971·Scottish Medical Journal·J I RobertsonM Tree
Mar 1, 1972·Circulation Research·C M FerrarioJ W McCubbin
Sep 1, 1965·The American Journal of Physiology·T N James
Aug 1, 1965·The Journal of Physiology·G P Lewis, E Reit
Nov 1, 1960·Circulation Research·S VARMAW B YOUMANS
Apr 1, 1964·Circulation Research·J KOCH-WESER
Feb 1, 1962·The American Journal of Physiology·S D NISHITHW B YOUMANS

❮ Previous
Next ❯

Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·A A AjayiJ L Reid
Jul 16, 1982·European Journal of Pharmacology·A NakashimaC I Johnston
Apr 28, 1993·European Journal of Pharmacology·J M SaavedraK Shigematsu
Oct 1, 1986·Journal of the Autonomic Nervous System·M J KilbornD I McCloskey
Nov 15, 1995·The American Journal of Cardiology·Y H ZhangL L Wan
Jul 18, 2002·Brain Research Bulletin·Steven L Bealer
Jun 1, 2000·Clinical and Experimental Pharmacology & Physiology·S L Bealer
Jul 1, 1982·The New England Journal of Medicine
Mar 1, 1981·Clinical and Experimental Pharmacology & Physiology·W B Lee, E R Lumbers
Sep 1, 1981·Clinical and Experimental Pharmacology & Physiology·E R Lumbers, I A Reid
Sep 1, 1993·British Journal of Pharmacology·M Rechtman, H Majewski
Jul 1, 1995·British Journal of Pharmacology·C Lambert
Feb 1, 1996·Journal of Cardiovascular Electrophysiology·H F ClemoB S Stambler
Feb 1, 1987·Acta Physiologica Scandinavica·B AnderssonM Wiberg
Oct 31, 2013·American Journal of Veterinary Research·Amanda Erickson ColemanScott A Brown
Jun 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·J ZhangP A van Zwieten
Jan 1, 1981·Pharmacology & Therapeutics·P I Korner, J A Angus
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·J Z XiangT Unger
Nov 1, 1990·American Heart Journal·K J OsterzielW Kübler
Dec 1, 1988·American Heart Journal·J B Kostis
Jan 1, 1984·The American Journal of Cardiology·H H RotmenschR K Ferguson
Dec 1, 1982·British Journal of Clinical Pharmacology·A SturaniP Zucchelli
Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C Irigoyen, E M Krieger
Nov 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jaya PamidimukkalaMeredith Hay
Apr 23, 2002·Journal of Human Hypertension·I Gavras, H Gavras
Feb 14, 2006·The Journal of Physiology·Susie J O'ConnorDino A Giussani
Oct 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Giulianna R BorgesRubens Fazan
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter S P TanRoger A L Dampney
Jan 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaya PamidimukkalaMeredith Hay
Oct 23, 2009·American Journal of Physiology. Cell Physiology·Libin ZhangYu-Long Li
Oct 31, 2001·Acta Anaesthesiologica Scandinavica·J UllmanM Rundgren
Sep 29, 2020·Hypertension·Joshua Wen-Han ChangRohit Ramchandra
Jan 1, 1987·Pharmacotherapy·M BorekW Frishman
Jan 1, 1987·British Journal of Clinical Pharmacology·R S Hornung, W S Hillis
Oct 12, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Stephanie J Wehlage, Francine G Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.