Jan 1, 1977

Mechanisms by which small molecules alter ionic permeability through lipid bilayer membranes

Advances in Experimental Medicine and Biology
G Szabo

Abstract

Small molecules may be particularly effective cytotoxic agents by way of altering ionic permeability in cell and organelle membranes. The mechanisms by which such molecules may acte on membrane permeability are examined here in light of the rather precise understanding of the mechanisms by which ionic permeability is induced and altered in lipid bilayer membranes. In particular, the influence of specific changes in membrane composition on the kinetics of direct and carrier mediated transport of ions are examined in detail and related to the electrical potentials originating from dipolar residues at the membrane surface.

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Mentioned in this Paper

Tissue Membrane
Electrolytes
Resting Potentials
Permeability
Cytotoxin
Quaternary Ammonium Compounds
ACTG2 wt Allele
Membranes, Artificial
ACTG2 gene
Cell Membrane Permeability

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