Mechanisms contributing to malignant dysrhythmias induced by ischemia in the cat

The Journal of Clinical Investigation
P B CorrB E Sobel


Continuously recorded bipolar electrograms were obtained simultaneously from epi-, endo-, and mid-myocardial regions of the ischemic and normal zones of cat left ventricle in vivo after coronary occlusion, analyzed by computer, and compared to regional cyclic AMP levels. Regional cyclic AMP content was used as an index of the combined local effects of: (a) efferent sympathetic nerve discharge; (b) release of myocardial catecholamines due to ischemia; and (c) circulating catecholamines. Ischemia resulted in a progressive increase in pulse width and rise time and a decrease in rate of rise of voltage (dV/dt) of the local electrograms from ischemic zones reaching a maximum within 2.4+/-0.3 min (mean+/-SE) at the time of onset of severe ventricular dysrhythmias, all of which returned toward control before the cessation of the dysrhythmia (33.5+/-1.5 min after coronary occlusion). Increases in cyclic AMP in ischemic zones preceded corresponding increases in the frequency of premature ventricular complexes (PVCs). Propranolol inhibited the increases in cyclic AMP and reduced the frequency of PVCs in animals without ventricular fibrillation. In animals with ventricular fibrillation, cyclic AMP was significantly elevated in normal and ...Continue Reading


Dec 6, 1972·Nature: New Biology·R W TsienP Greengard
Apr 1, 1973·Circulation Research·B E Sobel, S E Mayer
Oct 1, 1973·Circulation Research·J G Dobson, S E Mayer
Oct 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·C J LimasE D Freis
Aug 15, 1969·Biochemical and Biophysical Research Communications·A WollenbergerG Heier
Jul 8, 1972·British Medical Journal·S W WebbJ F Pantridge
Dec 1, 1972·The American Journal of Cardiology·M I KhanG W Manning
Sep 1, 1974·Circulation Research·R LazzaraB J Scherlag
Jun 1, 1966·American Heart Journal·A S Harris
Apr 1, 1970·Cardiovascular Research·P A EbertD C Sabiston
Jun 1, 1964·Circulation Research·J HANG K MOE

❮ Previous
Next ❯


Jul 1, 1996·Molecular and Cellular Biochemistry·A LochnerR Mouton
Oct 1, 1989·Pflügers Archiv : European journal of physiology·N A BurnashevL V Rosenshtraukh
Aug 1, 1993·Cardiovascular Drugs and Therapy·A A Wilde
Apr 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L P Krock, G H Hartung
Jul 1, 1981·Basic Research in Cardiology·T PodzuweitJ McCarthy
Jun 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M D CarcelesM L Laorden
Feb 3, 2012·Advances in Therapy·Ettore StrumiaGiuseppe D'Ambrosio
Nov 1, 1988·The American Journal of Cardiology·T KuzuyaM Tada
Dec 1, 1993·Pharmacology & Therapeutics·O E Brodde
Jul 1, 1989·Journal of the American College of Cardiology·J CincaA Salas-Caudevilla
Jan 1, 1990·Free Radical Biology & Medicine·G R HaenenA Bast
Mar 15, 2005·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Toshio MoritaniNarumi Nagai
Aug 7, 1980·The New England Journal of Medicine·J T Willerson
Jan 1, 1990·British Journal of Clinical Pharmacology·R H StrasserW Kübler
Jul 1, 1989·Clinical and Experimental Pharmacology & Physiology·C Y ZhanT M Wong
Jan 1, 1994·Journal of Cardiovascular Electrophysiology·E VanoliP J Schwartz
May 1, 1987·Acta Physiologica Scandinavica·L CarlssonL Svensson
Aug 1, 1980·British Heart Journal·K SwedbergI Wallentin
Sep 1, 1978·The Journal of Clinical Investigation·B E SobelM S Klein
Nov 1, 1979·The Journal of Clinical Investigation·A MukherjeeJ T Willerson
Jan 1, 1980·The Journal of Clinical Investigation·D J SheridanP B Corr
Nov 1, 1981·Journal of Pharmacological Methods·B Woodward
Jan 1, 1979·The American Journal of Cardiology·L H OpieW F Lubbe
Sep 1, 1981·The American Journal of Cardiology·P OuyangP J Varghese
Aug 1, 1987·Journal of Clinical Pharmacology·C M Lathers, W H Spivey
Aug 1, 1988·Journal of Clinical Pharmacology·C M LathersR M Levin
Dec 21, 1984·The American Journal of Cardiology·J T Willerson, L M Buja

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.