Mechanisms contributing to the response of upper-airway muscles to changes in airway pressure

Journal of Applied Physiology
Jayne C CarberryDanny J Eckert

Abstract

This study assessed the effects of inhaled lignocaine to reduce upper airway surface mechanoreceptor activity on 1) basal genioglossus and tensor palatini EMG, 2) genioglossus reflex responses to large pulses (∼10 cmH2O) of negative airway pressure, and 3) upper airway collapsibility in 15 awake individuals. Genioglossus and tensor palatini muscle EMG and airway pressures were recorded during quiet nasal breathing and during brief pulses (250 ms) of negative upper-airway pressure. Lignocaine reduced peak inspiratory (5.6 ± 1.5 vs. 3.8 ± 1.1% maximum; mean ± SE, P < 0.01) and tonic (2.8 ± 0.8 vs. 2.1 ± 0.7% maximum; P < 0.05) genioglossus EMG during quiet breathing but had no effect on tensor palatini EMG (5.0 ± 0.8 vs. 5.0 ± 0.5% maximum; P = 0.97). Genioglossus reflex excitation to negative pressure pulses decreased after anesthesia (60.9 ± 20.7 vs. 23.6 ± 5.2 μV; P < 0.05), but not when expressed as a percentage of the immediate prestimulus baseline. Reflex excitation was closely related to the change in baseline EMG following lignocaine (r(2) = 0.98). A short-latency genioglossus reflex to rapid increases from negative to atmospheric pressure was also observed. The upper airway collapsibility index (%difference) between nadi...Continue Reading

References

Jun 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J E RemmersA M Anch
Jul 1, 1976·The Journal of Physiology·C D MarsdenH B Morton
Jun 1, 1991·Journal of Applied Physiology·D J TangelD P White
Apr 1, 1990·Nihon juigaku zasshi. The Japanese journal of veterinary science·H Tsubone
Apr 1, 1989·Journal of Applied Physiology·R C BasnerJ W Weiss
Jul 1, 1988·Respiration Physiology·D Bartlett, W M St John
Sep 1, 1969·The Journal of Physiology·B S NailJ G Widdicombe
Oct 1, 1965·The Journal of Physiology·R W AngelA Iannone
Mar 1, 1984·Respiration Physiology·J C HwangD Bartlett
May 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E OnalT D O'Connor
Feb 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·O P MathewB T Thach
Nov 1, 1993·Experimental Physiology·A BradfordD McKeogh
Sep 1, 1993·The American Review of Respiratory Disease·J R WheatleyD P White
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·W S MezzanotteD P White
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·R B BerryR W Light
Sep 8, 1998·Journal of Applied Physiology·C WorsnopJ Trinder
Apr 6, 2000·Journal of Applied Physiology·R B FogelD P White
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·A MalhotraD P White
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·A MalhotraD P White
Mar 10, 2001·Respiration Physiology·J Widdicombe
Jul 14, 2001·Chest·A MalhotraD P White
Feb 20, 2004·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Hideto SaigusaSeiji Niimi
Mar 15, 2012·Respiratory Physiology & Neurobiology·Nicholas P S MurrayJane E Butler
Jun 1, 2013·American Journal of Respiratory and Critical Care Medicine·Danny J EckertAndrew Wellman

❮ Previous
Next ❯

Citations

Jan 24, 2018·Journal of Applied Physiology·Billy L LuuJane E Butler
Dec 30, 2017·The European Respiratory Journal·Jayne C CarberryDanny J Eckert
Aug 5, 2017·Annual Review of Neuroscience·David J Foster
Oct 28, 2019·Journal of Applied Physiology·Warren R RuehlandFergal J O'Donoghue
Mar 14, 2020·The European Respiratory Journal·Rodrigo T MartinsDanny J Eckert
Jun 4, 2020·Sleep & Breathing = Schlaf & Atmung·Clemens HeiserBenedikt Hofauer
Apr 26, 2019·Journal of Applied Physiology·Ferhat Erdogan, Mesut Sahin
Nov 11, 2020·American Journal of Respiratory and Critical Care Medicine·Clemens Heiser
Apr 16, 2021·Anesthesia and Analgesia·Thomas J AltreeDanny J Eckert
Dec 4, 2019·Annals of Physical and Rehabilitation Medicine·Antoine LéotardMaria Antonia Quera-Salva
May 31, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mei ZhuKevin Peng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.