Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signaling

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Annemie DeiterenBenedicte Y De Winter

Abstract

Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis. Trinitrobenzene sulfonic acid (TNBS)-colitis was monitored individually by colonoscopy to confirm colitis and follow convalescence and endoscopic healing in each rat. Experiments were performed in controls, rats with acute colitis and in postcolitis rats. Colonic afferent mechanosensitivity was assessed in vivo by quantifying visceromotor responses (VMRs), and by making extracellular afferent recordings from splanchnic nerve bundles in vitro. Multiunit afferent activity was classified into single units identified as low threshold (LT), wide dynamic range (WDR), high threshold (HT), and mechanically insensitive afferents (MIA). During acute TNBS-colitis, VMRs were significantly increased and splanchnic nerve recordings showed proportionally less MIA and increased WDR and HT afferents. Acute colitis gave rise to an enhanced spontaneous activity of both LT and MIA and augmented afferent mechanosensitivity in LT, WDR and...Continue Reading

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Citations

Feb 20, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B Y De WinterJ G De Man
Jul 4, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Saeed SiriBin Feng
Sep 5, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A DeiterenB Y De Winter
May 24, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Samuel Van RemoortelJean-Pierre Timmermans
Jan 22, 2020·Physiological Reports·Toni S TaylorEwan St John Smith

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