Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin

Frontiers in Physiology
Cao Nguyen Duong, Dietmar Vestweber

Abstract

Endothelial junctions provide blood and lymph vessel integrity and are essential for the formation of a vascular system. They control the extravasation of solutes, leukocytes and metastatic cells from blood vessels and the uptake of fluid and leukocytes into the lymphatic vascular system. A multitude of adhesion molecules mediate and control the integrity and permeability of endothelial junctions. VE-cadherin is arguably the most important adhesion molecule for the formation of vascular structures, and the stability of their junctions. Interestingly, despite this prominence, its elimination from junctions in the adult organism has different consequences in the vasculature of different organs, both for blood and lymph vessels. In addition, even in tissues where the lack of VE-cadherin leads to strong plasma leaks from venules, the physical integrity of endothelial junctions is preserved. Obviously, other adhesion molecules can compensate for a loss of VE-cadherin and this review will discuss which other adhesive mechanisms contribute to the stability and regulation of endothelial junctions and cooperate with VE-cadherin in intact vessels. In addition to adhesion molecules, endothelial receptors will be discussed, which stimulate...Continue Reading

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Citations

Aug 12, 2020·Lymphatic Research and Biology·Francine Blei
Nov 5, 2020·International Journal of Molecular Sciences·Priya VeluswamyJens Wippermann
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Klaus T PreissnerElisabeth Deindl
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Pieter R Norden, Tsutomu Kume
Mar 16, 2021·Frontiers in Cardiovascular Medicine·Johanna Hol FosseReidunn Edelmann
Feb 3, 2021·Canadian Journal of Physiology and Pharmacology·Duong Ngoc Diem NguyenYuh-Fen Pung

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Methods Mentioned

BETA
electron microscopy

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