Mechanisms for activating bacterial RNA polymerase.

FEMS Microbiology Reviews
Tamaswati GhoshXiaodong Zhang

Abstract

Gene transcription is a fundamental cellular process carried out by RNA polymerase (RNAP) enzymes and is highly regulated through the action of gene regulatory complexes. Important mechanistic insights have been gained from structural studies on multisubunit RNAP from bacteria, yeast and archaea, although the initiation process that involves the conversion of the inactive transcription complex to an active one has yet to be fully understood. RNAPs are unambiguously closely related in structure and function across all kingdoms of life and have conserved mechanisms. In bacteria, sigma (sigma) factors direct RNAP to specific promoter sites and the RNAP/sigma holoenzyme can either form a stable closed complex that is incompetent for transcription (as in the case of sigma(54)) or can spontaneously proceed to an open complex that is competent for transcription (as in the case of sigma(70)). The conversion of the RNAP/sigma(54) closed complex to an open complex requires ATP hydrolysis by enhancer-binding proteins, hence providing an ideal model system for studying the initiation process biochemically and structurally. In this review, we present recent structural studies of the two major bacterial RNAP holoenzymes and focus on mechanis...Continue Reading

References

Jun 1, 1992·Journal of Bacteriology·M LonettoC A Gross
Jan 4, 1969·Nature·R R BurgessE K Bautz
May 25, 1982·Journal of Molecular Biology·D K Hawley, W R McClure
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·S HillR Dixon
Mar 1, 1997·Molecular Microbiology·S Busby, R H Ebright
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·W V CannonM Buck
Jun 24, 1998·Journal of Molecular Biology·E SeverinovaS A Darst
Nov 18, 1998·FEMS Microbiology Reviews·M M Wösten
Jun 17, 1999·Journal of Molecular Biology·S Nechaev, K Severinov
Aug 28, 1999·The Journal of Biological Chemistry·M T GallegosM Buck
Nov 5, 1999·Journal of Molecular Biology·S Busby, R H Ebright
Jul 14, 2000·Journal of Bacteriology·M BuckJ D Gralla
Apr 3, 2001·Current Opinion in Microbiology·H Xu, T R Hoover
Apr 5, 2002·Molecular Cell·Elizabeth A CampbellSeth A Darst
May 10, 2002·Nature·Dmitry G VassylyevShigeyuki Yokoyama
Aug 16, 2002·Molecular Microbiology·X ZhangM Buck
Aug 31, 2002·Science·Brian BenoffRichard H Ebright
Jan 24, 2003·Genome Biology·Mark S B Paget, John D Helmann
Feb 13, 2003·Current Opinion in Structural Biology·Katsuhiko S Murakami, Seth A Darst
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Patricia BordesMartin Buck
Mar 6, 2003·Journal of Bacteriology·David J Studholme, Ray Dixon
May 17, 2003·The Journal of Biological Chemistry·Patricia C BurrowsSiva R Wigneshweraraj
May 20, 2003·Molecular Microbiology·Simon L DoveAnn Hochschild
Oct 7, 2003·Annual Review of Microbiology·Sergei Nechaev, Konstantin Severinov
Oct 7, 2003·Annual Review of Microbiology·Tanja M Gruber, Carol A Gross
Dec 23, 2003·The Journal of Biological Chemistry·Ben D HankamerJon Nield
Jan 21, 2004·Molecular Cell·Deepti JainSeth A Darst
Mar 24, 2004·Nature Reviews. Microbiology·Douglas F Browning, Stephen J Busby

❮ Previous
Next ❯

Citations

Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandy FilletJuan L Ramos
Apr 20, 2013·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Erika SalletThomas Schiex
Nov 5, 2011·Nucleic Acids Research·Shogo Ozaki, Tsutomu Katayama
Aug 4, 2012·Science·Anirban ChakrabortyRichard H Ebright
Jan 8, 2013·Journal of Bacteriology·Axel Cournac, Jacqueline Plumbridge
Aug 31, 2012·Microbiology and Molecular Biology Reviews : MMBR·Matthew Bush, Ray Dixon
Oct 22, 2011·Microbial Cell Factories·Kambiz Morabbi HeraviJosef Altenbuchner
Jan 1, 2011·Genetics Research International·Jessie ColinOdil Porrua
Aug 27, 2014·Journal of Molecular Biology·Natasha K VidangosDavid E Wemmer
Dec 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Bruno Y MatsuyamaMarcos V A S Navarro
Jun 12, 2012·Trends in Microbiology·Baojun Wang, Martin Buck
Jan 17, 2013·The FEBS Journal·Massimo SabbatiniGiovanni Bertoni
Jun 18, 2015·Nucleic Acids Research·Jorrit SchaeferMartin Buck
Aug 4, 2010·FEMS Microbiology Reviews·Juan L Ramos
Jun 26, 2012·Annual Review of Microbiology·David J LeeStephen J W Busby
Jul 1, 2017·Scientific Reports·José Manuel Borrero-de AcuñaIgnacio Poblete-Castro
Sep 22, 2017·Nucleic Acids Research·Kapil GoutamBalasubramanian Gopal
Aug 12, 2014·Applied and Environmental Microbiology·Danielle MoinierViolaine Bonnefoy
Aug 5, 2017·Journal of Industrial Microbiology & Biotechnology·Brady D LeePeter P Sheridan
Apr 21, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Yang Liu, Baojun Wang
Jun 20, 2020·Microbiology Resource Announcements·Wesley D RhinehartAlison E Kanak
Sep 29, 2019·Marine Drugs·Muhammad Tahir KhanDong Qing Wei
Feb 29, 2020·Biomolecules·Forson GaoXiaodong Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.