PMID: 9435628Jan 22, 1998Paper

Mechanisms for increased blood flow resistance due to leukocytes

The American Journal of Physiology
B P HelmkeG W Schmid-Schönbein

Abstract

Despite the small number of leukocytes relative to erythrocytes in the circulation, leukocytes contribute significantly to organ blood flow resistance. The present study was designed to investigate whether interactions between leukocytes and erythrocytes affect the pressure-flow relationship in a hemodynamically isolated rat gracilis muscle. At constant arterial flow rate, arterial pressure was increased significantly when relatively few physiological counts of leukocytes were added to a suspension containing erythrocytes at physiological hematocrits. However, the arterial pressure after perfusion of similar numbers of isolated leukocytes without erythrocytes was only slightly increased. An increase in resistance was also observed when leukocytes were replaced with 6-micron microspheres. We propose a new mechanism for increasing the hemodynamic resistance that involves hydrodynamic interactions between leukocytes and erythrocytes. In the presence of larger and less deformable leukocytes, erythrocytes move through capillaries more slowly than without leukocytes. Therefore erythrocytes are displaced from their axial positions. Slowing and radial displacement of erythrocytes serve to increase the relative apparent viscosity attrib...Continue Reading

References

Mar 6, 1992·The American Journal of Cardiology·J L MehtaW W Nichols
Nov 1, 1991·Journal of Biomechanical Engineering·D W Sutton, G W Schmid-Schönbein
Jan 1, 1989·Annals of Biomedical Engineering·D W SuttonG W Schmid-Schönbein
Feb 1, 1989·Pflügers Archiv : European journal of physiology·T N ThompsonG R Cokelet
Jan 1, 1980·Microvascular Research·G W Schmid-SchönbeinS Chien
Nov 1, 1994·Circulation Research·A R PriesP Gaehtgens
Apr 18, 1994·Annals of the New York Academy of Sciences·S KaulD D Heistad
Dec 1, 1995·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·L S RitterP F McDonagh
Sep 1, 1995·International Journal of Microcirculation, Clinical and Experimental·G W Schmid-Schönbein, J Lee

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Citations

Apr 3, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Şefik E ErdenerDavid A Boas
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S Bertuglia, A Colantuoni
Nov 10, 2001·Annual Review of Biomedical Engineering·T C Skalak
Nov 10, 2001·Annual Review of Biomedical Engineering·G W Schmid-Schönbein

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