Mechanisms for lateral turns in lamprey in response to descending unilateral commands: a modeling study

Biological cybernetics
Alexander K KozlovS Grillner

Abstract

Straight locomotion in the lamprey is, at the segmental level, characterized by alternating bursts of motor activity with equal duration and spike frequency on the left and the right sides of the body. Lateral turns are characterized by three main changes in this pattern: (1) in the turn cycle, the spike frequency, burst duration, and burst proportion (burst duration/cycle duration) increase on the turning side; (2) the cycle duration increases in both the turn cycle and the succeeding cycle; and (3) in the cycle succeeding the turn cycle, the burst duration increases on the non-turning side (rebound). We investigated mechanisms for the generation of turns in single-segment models of the lamprey locomotor spinal network. Activation of crossing inhibitory neurons proved a sufficient mechanism to explain all three changes in the locomotor rhythm during a fictive turn. Increased activation of these cells inhibits the activity of the opposite side during the prolonged burst of the turn cycle, and slows down the locomotor rhythm. Secondly, this activation of the crossing inhibitory neurons is accompanied by an increased calcium influx into the cells. This gives a suppressed activity on the turning side and a contralateral rebound af...Continue Reading

Citations

May 3, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Angela L Ridgel, Roy E Ritzmann
Nov 18, 2005·Biological cybernetics·Fernando CorbachoMichael A Arbib
Dec 21, 2006·Biological cybernetics·A K KozlovJ Hellgren Kotaleski
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Andreas A KardamakisSten Grillner
Oct 6, 2007·Brain Research Reviews·Sten GrillnerBrita Robertson
Jun 1, 2007·Neurocomputing·Carrie A Williams, Stephen P Deweerth
Sep 9, 2005·Current Opinion in Neurobiology·Sten GrillnerJeanette Hellgren Kotaleski
Aug 25, 2005·Trends in Neurosciences·Erik De SchutterAnders Lansner
Jan 27, 2015·Current Biology : CB·Francisco M OcañaSten Grillner
Aug 10, 2005·Brain, Behavior and Evolution·Melissa B McElligott, Donald M O'malley
Jul 3, 2003·Nature Reviews. Neuroscience·Sten Grillner
Jun 1, 2004·Physical Review Letters·Li ZhaopingSilvia Scarpetta

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