PMID: 8604546Nov 1, 1995Paper

Mechanisms for persistence of acute and chronic feline calicivirus infections in the face of vaccination

Veterinary Microbiology
N C Pedersen, K F Hawkins

Abstract

The study was concerned with possible reasons for the persistence of both acute and chronic feline calicivirus (FCV)-induced disease and sustained oral carriage in the field in the face of routine FCV immunization. It was concluded from this study that: 1) the original FCV-F9 strain, which is the basis of most live vaccines, still generates cross-reactive antibodies against almost all field strains in California, 2) vaccine strains derived from FCV-F9 may not be as broadly cross-protective as the parent strain, 3) whole inactivated FCV-2280 vaccine evokes high virus neutralizing antibody titers with an equally broad spectrum of cross-reactivity as FCV-F9, 4) all vaccine strains of FCV cause acute disease signs and protracted oral shedding when administered orally, 5) strains isolated from the mouth five to ten weeks following oral inoculation can differ from parental virus, usually appearing more vaccine resistant, 6) cats previously infected with field or vaccine strains develop much less severe acute illness when subsequently infected with heterologous FCV strains but are not protected against the chronic carrier state. Therefore, the persistence of FCV in the field cannot be explained solely by the emergence of vaccine resis...Continue Reading

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Citations

Mar 18, 2005·Journal of Feline Medicine and Surgery·Michael J Bannasch, Janet E Foley
May 26, 2005·Journal of Feline Medicine and Surgery·Bodil Ström HolstLena Englund
Oct 11, 2005·Journal of Feline Medicine and Surgery·Janet FoleyNiels C Pedersen
Aug 28, 2007·Journal of Feline Medicine and Surgery·Carol J PorterSusan Dawson
Jun 2, 2009·Journal of Feline Medicine and Surgery·Alan D RadfordMarian C Horzinek
Jun 5, 2003·International Journal for Parasitology·David Scott McVeySteven C Olson
Feb 22, 2002·Veterinary Microbiology·Vito MartellaCanio Buonavoglia
Aug 3, 2012·Journal of Virology·Karen P CoyneAlan D Radford
Jan 23, 2004·Journal of the American Veterinary Medical Association·Kate E HurleyJanet E Foley
Nov 3, 2006·Journal of the American Veterinary Medical Association·James R RichardsAndrew H Sparkes
Jul 22, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K Y Green
Aug 17, 2000·The Journal of Veterinary Medical Science·M MochizukiT Ishida
Oct 18, 2000·The Veterinary Clinics of North America. Small Animal Practice·D T Ramsey
Nov 28, 2006·Veterinary Microbiology·Barbara Di MartinoPolly Roy
Dec 3, 2016·The Journal of General Virology·Andrea M SpiriBarbara Willi
Jan 27, 2016·The Veterinary Record·J HouA D Radford
Apr 1, 1997·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·S E Turnquist, E Ostlund
Mar 20, 2018·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Joylson de Jesus PereiraTatiana Xavier de Castro
Feb 14, 2007·Veterinary Research·Alan D RadfordRosalind M Gaskell
Oct 27, 1999·The Journal of Veterinary Medical Science·M MochizukiT Ishida
Sep 3, 2020·Animals : an Open Access Journal From MDPI·Veronika VojtkovskáVladimír Večerek

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