Mechanisms for the age-related increase in fatigability of the knee extensors in old and very old adults

Journal of Applied Physiology
Christopher W SundbergSandra K Hunter

Abstract

The mechanisms for the age-related increase in fatigability during high-velocity contractions in old and very old adults (≥80 yr) are unresolved. Moreover, whether the increased fatigability with advancing age and the underlying mechanisms differ between men and women is not known. The purpose of this study was to quantify the fatigability of knee extensor muscles and identify the mechanisms of fatigue in 30 young (22.6 ± 0.4 yr; 15 men), 62 old (70.5 ± 0.7 yr; 33 men), and 12 very old (86.0 ± 1.3 yr; 6 men) men and women elicited by high-velocity concentric contractions. Participants performed 80 maximal velocity contractions (1 contraction per 3 s) with a load equivalent to 20% of the maximum voluntary isometric contraction. Voluntary activation and contractile properties were quantified before and immediately following exercise (<10 s) using transcranial magnetic stimulation and electrical stimulation. Absolute mechanical power output was 97 and 217% higher in the young compared with old and very old adults, respectively. Fatigability (reductions in power) progressively increased across age groups, with a power loss of 17% in young, 31% in old, and 44% in very old adults. There were no sex differences in fatigability among a...Continue Reading

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Citations

Mar 30, 2018·Journal of Applied Physiology·Jonathon SenefeldSandra K Hunter
Nov 9, 2018·The Journal of Physiology·Aurora D FosterChad R Straight
Apr 25, 2019·The Journal of Physiology·Christopher W SundbergSandra K Hunter
Oct 11, 2019·The Journal of Physiology·Rachel K Fenech, Chantal R Ryan
Nov 7, 2019·Medicine and Science in Sports and Exercise·Vianney RozandAshleigh E Smith
Apr 30, 2020·American Journal of Physiology. Cell Physiology·Laura E TeigenRobert H Fitts
Jul 8, 2020·Physiological Reports·Jonathon W SenefeldSandra K Hunter
Aug 14, 2020·European Journal of Applied Physiology·MinHyuk KwonSandra K Hunter
Jan 29, 2019·Frontiers in Physiology·Paul M CoenBenjamin F Miller
Dec 4, 2020·Journal of Applied Physiology·James L NuzzoJanet L Taylor
Feb 19, 2020·Experimental Gerontology·Renata L KrügerGuillaume Y Millet
May 1, 2021·International Journal of Environmental Research and Public Health·Ryan M MillerMichael G Bemben
Aug 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Giorgio VarescoVianney Rozand

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