PMID: 7528915Jan 1, 1994Paper

Mechanisms for the elimination of potentially lytic complement-fixing variable surface glycoprotein antibody-complexes in Trypanosoma brucei

Parasitology Research
D C RussoD J Grab

Abstract

Live antibody-coated Trypanosoma brucei parasites remove variable surface glycoprotein (VSG)-antibody complexes from their surface upon warming to 37 degrees C and evade antibody-activated complement lysis by both protein synthesis-dependent and protein synthesis-independent mechanisms. The protein synthesis-dependent process follows antibody-mediated trypanosome agglutination, whereas the protein synthesis-independent mechanism can occur in the absence of trypanosome agglutination. The latter process leads to a more rapid elimination of complement-fixing VSG-antibody complexes.

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Citations

Apr 6, 2005·Veterinary Immunology and Immunopathology·Emmeline W HillDavid E MacHugh
Jun 20, 2002·Veterinary Immunology and Immunopathology·J NaessensM Sileghem
May 9, 2008·PLoS Biology·Mélanie BonhiversDerrick R Robinson
Oct 16, 2012·Molecular Immunology·Igor CestariMarcel I Ramirez
Dec 5, 2006·Anais Da Academia Brasileira De Ciências·Philippe Vincendeau, Bernard Bouteille
Apr 23, 2003·The Journal of Biological Chemistry·Douglas J LaCountJohn E Donelson
Jan 26, 2011·Parasite Immunology·B Namangala
Jan 14, 2017·Frontiers in Microbiology·Alicia Ponte-Sucre
Nov 4, 2004·Traffic·Mark C Field, Mark Carrington
Oct 10, 1998·Clinical Microbiology Reviews·E Y Denkers, R T Gazzinelli

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