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Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error

bioRxiv

Nov 7, 2019

Neil T UmbreitDavid S Pellman

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Abstract

The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. Signatures of BFB cycles can be observed in cancer genomes with chromothripsis, another catastrophic mutational process. Here, we explain this association b...read more

Mentioned in this Paper

Actomyosin
Malignant Neoplasms
Cell Division
Centromere
Chromosomes
DNA
DNA Damage
Biological Evolution
Gene Amplification
Genome
21
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Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error

bioRxiv

Nov 7, 2019

Neil T UmbreitDavid S Pellman

DOI: 10.1101/835058

Abstract

The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. Signatures of BFB cycles can be observed in cancer genomes with chromothripsis, another catastrophic mutational process. Here, we explain this association b...read more

Mentioned in this Paper

Actomyosin
Malignant Neoplasms
Cell Division
Centromere
Chromosomes
21

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