Mechanisms in hyperkalemic renal tubular acidosis

Journal of the American Society of Nephrology : JASN
F E Karet

Abstract

The form of renal tubular acidosis associated with hyperkalemia is usually attributable to real or apparent hypoaldosteronism. It is therefore a common feature in diabetes and a number of other conditions associated with underproduction of renin or aldosterone. In addition, the close relationship between potassium levels and ammonia production dictates that hyperkalemia per se can lead to acidosis. Here I describe the modern relationship between molecular function of the distal portion of the nephron, pathways of ammoniagenesis, and hyperkalemia.

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Related Concepts

Metabolic Acidosis
Renal Tubular Acidosis, Type II
Aldosterone, (11 beta,17 alpha)-Isomer
Ammonia
Hyperkalemia
Renal Tubule Structure
Nephrons
Potassium
Epithelial sodium channel
Acidosis

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