PMID: 7542736May 1, 1995Paper

Mechanisms in the induction of neuronal heterotopiae following prenatal cytotoxic brain damage

Neurotoxicology and Teratology
L L ZhangK W Ashwell

Abstract

Prenatal exposure to several neuroteratogens, such as ionizing radiation, ethanol, and cytotoxic drugs, induces the development of clusters of abnormally positioned neurons within the brain. These abnormalities have always been presumed to result from interference with normal neuronal migration, presumably via effects on radial glia. In our study, pregnant rats were injected with methylazoxymethanol acetate (MAM) on either E13, E14, or E15. Computerised reconstruction techniques, Golgi and immunocytochemical staining as well as electron microscopy were used to detect structural abnormalities of radial glia which might be responsible for the production of heterotopiae. Several structural abnormalities such as microcavitation, involvement of radial glial elements in rosettes, disturbance of the normal ventricular lining, and disruption of the attachment of radial glial endfeet to the pial surface were identified. We propose that periventricular heterotopiae result from disruption of the palisade arrangement of neuroepithelial cells in the ventricular zone and the involvement of radial glial elements in rosettes. Layer I heterotopiae may arise from abnormalities of the distal segments of radial glia and their attachment to the pia...Continue Reading

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Citations

Oct 9, 1999·Epilepsy Research·K M JacobsD A Prince
Jul 14, 1999·Epilepsia·N Chevassus-au-LouisY Ben-Ari
Dec 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuanyi FengChristopher A Walsh
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·N Chevassus-Au-LouisJ L Gaïarsa
Sep 3, 2014·CNS Neuroscience & Therapeutics·Françoise WatrinAlfonso Represa
May 31, 2014·International Journal of Neural Systems·Beata StrackKrzysztof J Cios
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jean-Bernard Manent, Alfonso Represa
Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·P A Schwartzkroin, C A Walsh
Oct 7, 2017·Epilepsia·Francesca PizzoFabrice Bartolomei
Jun 24, 2000·International Journal of Radiation Biology·Y KubotaK Yoshida
Sep 15, 2001·Journal of Neuropathology and Experimental Neurology·M R Santi, J A Golden

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