Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets

Journal of Agricultural and Food Chemistry
Joen-Rong SheuDuen-Suey Chou

Abstract

The aim of this study was to systematically examine the inhibitory mechanisms of rutin, a well-known flavonoid in platelet aggregation. In this study, rutin concentration-dependently (250 and 290 microM) inhibited platelet aggregation in human platelets stimulated by agonists (i.e., collagen). Rutin (250 and 290 microM) did not significantly interfere with the binding of FITC-triflavin to the glycoprotein IIb/IIIa complex in human platelets. Rutin (250 and 290 microM) markedly inhibited intracellular Ca(2+) mobilization and thromboxane A(2) formation in human platelets stimulated by collagen. Rapid phosphorylation of a platelet protein of M(r) 47000 (P47), a marker of protein kinase C activation, was triggered by collagen (1 microg/mL). This phosphorylation was markedly inhibited by rutin (250 and 290 microM). On the other hand, rutin (250 and 290 microM) did not significantly increase the formations of cyclic AMP and nitric oxide/cyclic GMP in platelets. In conclusion, these results indicate that the antiplatelet activity of rutin may involve the following pathways: rutin inhibited the activation of phospholipase C, followed by inhibition of protein kinase C activity and thromboxane A(2) formation, thereby leading to inhibitio...Continue Reading

References

Oct 18, 1976·Biochemical and Biophysical Research Communications·I F CharoT C Detwiler
Jul 1, 1991·Carcinogenesis·E E DeschnerH L Newmark
Jan 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·L J McDonald, F Murad

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Citations

Mar 23, 2011·Journal of Agricultural and Food Chemistry·Hyun-Jin KimJeong-Ho Lim
Jul 24, 2013·Journal of Agricultural and Food Chemistry·Chiu-Lan HsiehRobert Y Peng
Oct 2, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Stephan C Bischoff
May 9, 2012·The Journal of Clinical Investigation·Reema JasujaRobert Flaumenhaft
Aug 2, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kibbeum SongJungkee Kwon
Apr 5, 2016·Pharmacognosy Magazine·Grandhi Venkata RamalingayyaKrishnadas Nandakumar
Mar 9, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ayman Moawad Mahmoud
Mar 5, 2016·Journal of Industrial Microbiology & Biotechnology·Dae Gyun AnJoong-Hoon Ahn
May 11, 2010·Epilepsy & Behavior : E&B·Marjan Nassiri-AslEsmail Abbasi
Nov 17, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marjan Nassiri-AslMohsen Ganjvar
Aug 12, 2008·Clinics in Dermatology·Jacek Arct, Katarzyna Pytkowska
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marjan Nassiri-AslFarzaneh Zamansoltani
Jan 30, 2009·Basic & Clinical Pharmacology & Toxicology·Amir ZiaeeEsmail Abbasi
Mar 23, 2011·Phytotherapy Research : PTR·Dao-quan TangXiang-lan Jiang
Sep 1, 2011·Phytotherapy Research : PTR·Gustavo R M BarcelosFernando Barbosa
Apr 15, 2016·Redox Report : Communications in Free Radical Research·Tomáš FilipskýPřemysl Mladěnka
Jul 29, 2006·Journal of Ethnopharmacology·C A O FéresC A Tagliati
Mar 18, 2015·Journal of Bioscience and Bioengineering·Jun-Hui ChoiSeung Kim
Jun 19, 2013·Food Chemistry·Maria Elisa Melo Branco de AraújoPatrícia de Oliveira Carvalho
Jan 31, 2012·Medical Hypotheses·Elena AlbuIvan Sosa
Sep 7, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Ying-Chen YangYi-Lin Sophia Chen
Aug 6, 2014·TheScientificWorldJournal·Azizah UgusmanZaleha Abdullah Mahdy
Apr 8, 2016·Expert Opinion on Drug Metabolism & Toxicology·Thanasekaran JayakumarJoen-Rong Sheu
Nov 23, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Amira SalehWaleed Barakat
Mar 22, 2019·Critical Reviews in Food Science and Nutrition·Montaña CámaraMachteld van Lieshout
Oct 10, 2019·Mini Reviews in Medicinal Chemistry·Alexey V DobrydnevMaria V Popova
May 26, 2016·International Journal of Molecular Medicine·Seong Jin ChoiHwa Jun Cha
Mar 29, 2020·Animal Science Journal = Nihon Chikusan Gakkaihō·Dejun XuQingwang Li
Jun 14, 2013·Experimental Biology and Medicine·Jin Kyeong Choi, Sang-Hyun Kim

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