Mechanisms mediating environmental chemical-induced endocrine disruption in the adrenal gland

Frontiers in Endocrinology
D B Martinez-Arguelles, V Papadopoulos

Abstract

Humans are continuously exposed to hundreds of man-made chemicals that pollute the environment in addition to multiple therapeutic drug treatments administered throughout life. Some of these chemicals, known as endocrine disruptors (EDs), mimic endogenous signals, thereby altering gene expression, influencing development, and promoting disease. Although EDs are eventually removed from the market or replaced with safer alternatives, new evidence suggests that early-life exposure leaves a fingerprint on the epigenome, which may increase the risk of disease later in life. Epigenetic changes occurring in early life in response to environmental toxicants have been shown to affect behavior, increase cancer risk, and modify the physiology of the cardiovascular system. Thus, exposure to an ED or combination of EDs may represent a first hit to the epigenome. Only limited information is available regarding the effect of ED exposure on adrenal function. The adrenal gland controls the stress response, blood pressure, and electrolyte homeostasis. This endocrine organ therefore has an important role in physiology and is a sensitive target of EDs. We review herein the effect of ED exposure on the adrenal gland with particular focus on in uter...Continue Reading

References

Jan 1, 1976·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·G N Gill
Nov 17, 1990·BMJ : British Medical Journal·D J Barker
Apr 4, 1986·Science·M S Brown, J L Goldstein
Oct 1, 1994·Toxicology and Applied Pharmacology·B J DavisJ J Heindel
Aug 27, 1993·Cell·J A KreidbergR Jaenisch
Jul 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·O HatanoK Morohashi
Jun 1, 1997·Endocrine Reviews·S Mesiano, R B Jaffe
Dec 8, 1998·Nature Genetics·R N YuJ L Jameson
Jul 2, 1999·Regulatory Toxicology and Pharmacology : RTP·J DoullM van Gemert
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J OsugaN Yamada
Apr 12, 2001·Reproductive Toxicology·J H DeesV Papadopoulos
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yanhong ShiRonald M Evans
Aug 21, 2002·Trends in Endocrinology and Metabolism : TEM·Catherine E Keegan, Gary D Hammer
Oct 5, 2002·Journal of Lipid Research·Fredric B Kraemer, Wen-Jun Shen
Apr 24, 2003·International Journal of Hygiene and Environmental Health·Holger M KochJürgen Angerer
Nov 5, 2003·Environmental Health Perspectives·Giuseppe LatiniPietro Mazzeo
Dec 4, 2003·Biochemical Society Transactions·C Holm
Dec 3, 2003·Trends in Endocrinology and Metabolism : TEM·Margery A Connelly, David L Williams
Mar 27, 2004·Physiological Reviews·András Spät, László Hunyady
Mar 30, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K F JepsenS T Larsen
May 4, 2004·Environmental Health Perspectives·Russ HauserAntonia M Calafat
Jun 17, 2004·Environmental Health Perspectives·Theo Colborn
Sep 15, 2004·Bulletin of Environmental Contamination and Toxicology·M J SilvaA M Calafat
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·Hyun Jung Koo, Byung Mu Lee
Dec 18, 2004·Endocrinology·Gary D HammerBernard P Schimmer
Jan 26, 2005·Endocrine Research·Mary H BassettWilliam E Rainey
Jun 4, 2005·Analytical and Bioanalytical Chemistry·Gerda K MortensenNiels E Skakkebaek
Jul 13, 2005·Journal of Toxicology and Environmental Health. Part a·Hyun Jung Koo, Byung Mu Lee
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christopher Paul Wild

❮ Previous
Next ❯

Citations

Jan 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Alex OdermattRoger T Engeli
Oct 17, 2015·Journal of Veterinary Pharmacology and Therapeutics·M ZhuM J Myers
Jul 24, 2015·Environmental Science and Pollution Research International·Lílian Cristina PereiraDaniel Junqueira Dorta
Mar 31, 2016·International Journal of Environmental Research and Public Health·Huixiao HongWeida Tong
Jul 15, 2016·Reproductive Toxicology·Lusine YaghjyanSu-Hsin Chang
Apr 28, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Randall JenkinsDavid Rozansky
Apr 16, 2019·Frontiers in Endocrinology·Rosa LaurettaMarialuisa Appetecchia
Feb 10, 2021·Environmental Science and Pollution Research International·Jiwon OnHeesoo Pyo
Feb 20, 2021·Annals of Work Exposures and Health·Pornpimol KongtipSusan R Woskie
Nov 30, 2018·Environmental Research·Vicente MustielesUNKNOWN Environment and Reproductive Health (EARTH) Study Team
May 1, 2021·Toxics·Randall JenkinsDavid Rozansky
Aug 4, 2021·Biology of Reproduction·Wei Yan

❮ Previous
Next ❯

Methods Mentioned

BETA
in silico methods
transfection
RRBS

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Cardiovascular Risk Reduction

Prevention of cardiovascular disease is an important health initiative. Risk reduction including physical activity, smoking cessation, diet, blood pressure lowering drugs and pharmacotherapy. Here is the latest research on cardiovascular risk reduction.