Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat

Neuroscience
Luiz F FerrariPaul G Green

Abstract

Nitroglycerin (glycerol trinitrate, GTN) induces headache in migraineurs, an effect that has been used both diagnostically and in the study of the pathophysiology of this neurovascular pain syndrome. An important feature of this headache is a delay from the administration of GTN to headache onset that, because of GTN's very rapid metabolism, cannot be due to its pharmacokinetic profile. It has recently been suggested that activation of perivascular mast cells, which has been implicated in the pathophysiology of migraine, may contribute to this delay. We reported that hyperalgesia induced by intradermal GTN has a delay to onset of ∼ 30 min in male and ∼ 45 min in female rats. This hyperalgesia was greater in females, was prevented by pretreatment with the anti-migraine drug, sumatriptan, as well as by chronic pretreatment with the mast cell degranulator, compound 48/80. The acute administration of GTN and compound 48/80 both induced hyperalgesia that was prevented by pretreatment with octoxynol-9, which attenuates endothelial function, suggesting that GTN and mast cell-mediated hyperalgesia are endothelial cell-dependent. Furthermore, A-317491, a P2X3 antagonist, which inhibits endothelial cell-dependent hyperalgesia, also preve...Continue Reading

References

Jan 1, 1985·The American Journal of Cardiology·P K Noonan, L Z Benet
Aug 15, 1995·The Journal of Physiology·H Holthusen, J O Arndt
Nov 1, 1994·International Archives of Allergy and Immunology·G JafferyE B Bell
Oct 1, 1994·Cardiovascular Drugs and Therapy·M G Bogaert
Mar 1, 1994·British Journal of Pharmacology·M G PerssonL E Gustafsson
Mar 1, 1993·Canadian Journal of Physiology and Pharmacology·J P BourreauC E Challice
Sep 5, 2002·European Journal of Pharmacology·Giorgio SandriniGiuseppe Nappi
Mar 7, 2003·European Journal of Pharmacology·Cristina TassorelliGiuseppe Nappi
Jan 28, 2004·British Journal of Pharmacology·Anna P PiovezanGiles A Rae
Apr 20, 2006·JAMA : the Journal of the American Medical Association·Jan Lewis Brandes
Feb 14, 2007·Glycobiology·Albana CumashiUNKNOWN Consorzio Interuniversitario Nazionale per la Bio-Oncologia, Italy
Jan 22, 2008·Journal of Leukocyte Biology·Thiago M CunhaFernando Q Cunha
Jul 18, 2009·Stroke; a Journal of Cerebral Circulation·Gretchen E TietjenSadik A Khuder
Mar 19, 2011·Annals of Neurology·Mohammad S AsgharMessoud Ashina
Jun 3, 2011·Headache·Saurabh GuptaB Lee Peterlin
Jun 7, 2011·Molecular Pain·Dimitris N XanthosJürgen Sandkühler
Sep 13, 2011·Blood·Christian A KunderSoman N Abraham
Dec 14, 2011·Experimental Neurology·Elizabeth K Joseph, Jon D Levine
Apr 24, 2012·CNS Drugs·Peer Tfelt-Hansen, Jes Olesen
Jul 26, 2012·Biochemical and Biophysical Research Communications·Devavani ChatterjeaTijana Martinov
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth K JosephJon D Levine
May 16, 2013·The Annals of Pharmacotherapy·Ashley E WoodruffStephanie J Seyse
Sep 3, 2013·Biological & Pharmaceutical Bulletin·Takuji MachidaMasahiko Hirafuji
Oct 15, 2013·Pain·Amynah A PradhanAndrew Charles
May 3, 2014·Journal of Neurophysiology·Xiaojie ChenJon D Levine
Oct 5, 2014·Cephalalgia : an International Journal of Headache·Gretchen E Tietjen, Jagdish Khubchandani

❮ Previous
Next ❯

Citations

Oct 27, 2016·Neuroscience·Blaine Jacobs, Gregory Dussor
Jul 21, 2016·Neuroscience Letters·Fereshteh FarajdokhtGisou Mohaddes
Sep 19, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nastaren AbadSamuel C Grant
Feb 7, 2018·Acta Neurologica Scandinavica·T P DoH W Schytz
Jul 10, 2018·Brain : a Journal of Neurology·Ilaria Maddalena MaroneSerena Materazzi
Aug 10, 2017·Molecular Medicine Reports·Yun-Yong LiuQian Tian
Dec 21, 2019·Cephalalgia : an International Journal of Headache·Erika Ivanna ArayaJuliana Geremias Chichorro
May 21, 2018·Current Pain and Headache Reports·Tse-Ming Chou, Shih-Pin Chen
Jun 30, 2019·Disease Models & Mechanisms·Lucie ValekIrmgard Tegeder
Apr 1, 2020·Cephalalgia : an International Journal of Headache·Sarah L ChristensenDavid M Kristensen
Nov 15, 2020·Journal of Neuroscience Methods·Cynthia AbboudMarc Landry
Jul 14, 2021·Pain·Ann M GregusMatthew W Buczynski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.