Mechanisms mediating the coronary vascular response to behavioral stress in the dog

Circulation Research
G E Billman, D C Randall

Abstract

Left circumflex coronary blood flow (CBF) was measured in eight mongrel dogs with 8 MHz continuous wave Doppler flow transducers during classical aversive conditioning. The cardiovascular condition response consisted of significant (P less than 0.01) increases in: (1) mean aortic pressure (16.1%), (2) d(left ventricular pressure)/dt (64.2%), and (3) heart rate (63.2%). The coronary vascular response to behavioral stress consisted of an initial late diastolic decrease in CBF (12.5%) between 5 and 10 seconds after conditional stimulus onset, followed by a significant increase in CBF (96.8%). Concurrently, late diastolic coronary vascular resistance (CVR) first significantly increased (21.9%), then significantly decreased (39.8%). The increase in CVR was attenuated by cardiac pacing and converted into a significant decrease after alpha-receptor blockade. The decrease in CVR was reduced either by cardiac pacing or cardioselective beta-receptor blockage and eliminated by the combination of alpha- and beta-receptor blockade. Thus, these data indicate that the coronary vascular response to stress consisted of two components: an initial alpha-adrenergic coronary vasoconstriction, followed by a more complex vasodilation which was probab...Continue Reading

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Citations

Jan 1, 1992·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·G E Billman
Jul 1, 1993·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·D C RandallK R Powell
Sep 1, 1986·Journal of the Autonomic Nervous System·G E Billman, L V Bickerstaff
Feb 1, 1988·Journal of the Autonomic Nervous System·G E Billman
Jun 1, 1988·Journal of the Autonomic Nervous System·S R VallanceD C Randall
Mar 1, 1990·Journal of the Autonomic Nervous System·G E BillmanJ F Zolman
May 10, 2001·Journal of the American College of Cardiology·J A KovachR L Verrier
Sep 7, 2006·Journal of Cardiovascular Pharmacology·Susan Xiuqing ZhaoRichard L Verrier
Jan 1, 1984·Annals of the New York Academy of Sciences·R L Verrier, B Lown
Mar 1, 1995·The American Journal of Cardiology·C R LacyJ B Kostis
Dec 1, 1986·Archives of Emergency Medicine·L J Freeman, P G Nixon

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